PMID: 45889Jan 1, 1975

"Pure" monocytic or histiomonocytic leukemia: a revised concept

Cancer
M T Shaw, R E Nordquist

Abstract

In a series of 130 cases of acute leukemia studied by cytochemical staining techniques, 10 cases cytochemically diagnosed as "pure" monocytic leukemia were seen. Cytochemical staining of bone marrow aspirates from these patients revealed all leukemic cells to be Sudan black negative. No positive reactions were observed for peroxidase or naphthol AS-D chloroacetate esterase. All cases demonstrated strong alpha-naphthyl acetate esterase positivity; and fluoride-inhibited naphthol AS-D acetate esterase positivity was observed in 8 of 9 cases tested. The P.A.S. reaction showed diffuse fine to coarse granules. Oil red O stain was positive in 8 of 9 cases, and the beta-glucuronidase activity was strong in 5 of 9 cases. Light microscopy revealed cells with monocytic or histiocytic morphology. Electron microscopic studies in 2 cases demonstrated features consistent with leukemic monocytic or histiocytic morphology; none was suggestive of granulocytic or lymphocytic leukemia. Five of 6 patients treated with drug regimens including prednisone and vincristine entered a complete remission; the other obtained a partial remission. Two patients achieved complete remission after treatment with Adriamycin, 1 following a relapse. Three patients ...Continue Reading

References

Dec 1, 1977·British Journal of Haematology·C Sundström, K Nilsson
Jan 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·L Kass
Jan 1, 1978·American Journal of Hematology·M T Shaw
Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·T ShimboH Okada
Sep 1, 1982·American Journal of Hematology·B F Burns, W K Evans
Apr 1, 1982·American Journal of Hematology·I MirchandaniM Palutke
Dec 1, 1981·The Journal of the American Dental Association·S B Sydney, F Serio
Oct 1, 1985·Cancer·P J DarbyshireM G Mott
Mar 15, 1980·Cancer·L Glasser
Sep 1, 1978·Scandinavian Journal of Haematology·J C CawleyB E Roberts
May 1, 1996·Annals of Saudi Medicine·L A Al-GwaizA A Al-Nasser
Mar 1, 1979·Veterinary Pathology·D V TolleW P Norris
Mar 1, 1983·Scandinavian Journal of Haematology·I MirchandaniC R Bishop

Citations

Feb 1, 1974·American Journal of Clinical Pathology·M T Shaw, V A Klemp
Jan 1, 1973·Cancer·H R SchumacherS A Park
Jan 1, 1968·Acta Haematologica·F Schmalzl, H Braunsteiner
Jun 1, 1968·British Journal of Haematology·L RozenszajnJ Epstein
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Apr 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M HAYASHIW H FISHMAN

Related Concepts

Ovoperoxidase
Cytarabine
Cytonal
Remission, Spontaneous
Oil red O
Acute Leukemia
Fluoride Measurement
Science of Morphology
Bone Marrow
Peroxidases

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