Pure pancreatic juice from patients with chronic pancreatitis has an impaired antibacterial activity

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
F MarottaG Barbi

Abstract

These data show that pure pancreatic juice of AICP patients has a markedly defective antibacterial activity. This finding might be of potential clinical interest in the understanding of the pathophysiology of the disease. The aim of the present study was to test the antibacterial activity of pure pancreatic juice in patients with chronic pancreatitis. The study group consisted of ten patients with ethanol-induced chronic pancreatitis (AICP) and seven control patients free of pancreatic disease. All subjects had recently undergone a secretin-pancreozymin pancreatic function test. After an overnight fast, through a side-viewing endoscope, selective pancreatic duct cannulation was performed. After secretin stimulation, pure pancreatic juice was obtained. Three fractions of different molecular weights were separated. Samples were incubated with 1-mL suspension of 10(5) Escherichia coli ATCC 25,922, and log10 of colony-forming units were counted. Experiments were repeated by grading pancreatic juice concentration, pH of the medium, and inoculum size. No significant change of pH of pure pancreatic juice appeared between AICP and controls. Starting from 6-h observation, pure pancreatic juice of AICP patients showed a significant bacte...Continue Reading

References

May 18, 1977·Medical Microbiology and Immunology·O Felsenfeld, K Gyr
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Citations

Jan 1, 2008·Case Reports in Gastroenterology·Liliane S DeebC S Pitchumoni

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