PMID: 428831Feb 1, 1979Paper

Pure pancreatic juice studies in normal subjects and patients with chronic pancreatitis

Gut
M E Denyer, P B Cotton

Abstract

Pure pancreatic juice was obtained from within the pancreatic duct in 54 patients after endoscopic cannulation of the papilla of Vater. In all 20 normal subjects there was a brisk response to intravenous injections of GIH secretin in small dosage (1 and 4 CU). Peak bicarbonate concentrations occurred after a 4 CU stimulus, whereas volumes, and bicarbonate and protein outputs were greatest after 70 CU. Total protein and amylase concentrations were highest in the first specimens collected from each patient, and fell rapidly after stimulation. Plateau levels for all indices were achieved 10-20 minutes after starting infusions of secretin and pancreozymin. When normal patients and those with chronic pancreatitis were compared, there was considerable overlap in all indices (volume, bicarbonate and total protein concentrations) after bolus injections of secretin. Most patients with chronic pancreatitis achieved a peak bicarbonate concentration in excess of 100 mmol/l. The median concentrations were not significantly different from normal after any dose of secretin when pooled 10 minute samples were analysed. However there were significant differences in peak bicarbonate concentrations (after 1 and 4 CU, but not after 70 CU), when one...Continue Reading

Citations

Dec 1, 1979·Digestive Diseases and Sciences·J Sahel, H Sarles
Feb 1, 1997·Annals of Surgery·J Geoghegan, T N Pappas
Sep 1, 1982·Gut·P G Lankisch
May 29, 2008·World Journal of Gastroenterology : WJG·John G Lieb, Peter V Draganov
Nov 3, 2011·World Journal of Gastroenterology : WJG·Tyler Stevens, Mansour A Parsi
Sep 17, 2009·Digestive Diseases and Sciences·Kathryn M DalbecNicholas J Zyromski
Aug 1, 1982·Gastrointestinal Endoscopy·J A Gregg
Sep 16, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Anita BalázsUNKNOWN Hungarian Pancreatic Study Group
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Jul 25, 2015·Clinics and Research in Hepatology and Gastroenterology·Anita Balázs, Péter Hegyi
Sep 24, 2016·Abdominal Radiology·Temel TirkesKumaresan Sandrasegaran
Sep 19, 2019·American Journal of Physiology. Cell Physiology·Takashi MunemasaJames E Melvin
May 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Karoly HorvathIvor D Hill
Jun 1, 1987·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·E J Boyd, K G Wormsley
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Feb 1, 1994·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·H OhtaH Takahashi

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