Pure red cell aplasia as first manifestation of splenic marginal zone lymphoma-successful treatment with rituximab: a case report.

Cases Journal
Athanasios AnastasiadisConstantinos Tsatalas

Abstract

Acquired pure red cell aplasia is a rare disorder, usually appearing secondary to various pathologic conditions such as thymoma, systemic autoimmune diseases or in the course of lymphomas. Conventional treatment consists of immunosuppression with corticosteroids, antithymocyte globulin or cyclosporin-A. 8 weekly courses of rituximab were administered to a patient who presented with pure red cell aplasia secondary to newly diagnosed splenic marginal zone lymphoma. Transfusion independence was achieved after the 6(th) course, and pure red cell aplasia receded completely with therapy. Pure red cell aplasia may ensue early in the course of splenic marginal zone lymphoma and other low grade lymphomas. Rituximab is a safe and effective alternative treatment for pure red cell aplasia secondary to lymphoproliferative disorders.

References

Apr 17, 1999·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S DuttaH P Pati
Mar 28, 2001·Ryōikibetsu shōkōgun shirīzu·M Teramura
Oct 22, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M DjaldettiH Bessler
Nov 4, 2004·European Journal of Haematology·Nicole CasadevallJérôme Rossert
Dec 1, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Despina PantelidouGeorge Bourikas
Mar 31, 2005·Brain, Behavior, and Immunity·Cobi J Heijnen
May 22, 2007·Hematological Oncology·C KalpadakisM K Angelopoulou
Feb 14, 2008·Hematological Oncology·Michael BennettGeraldine P Schechter
May 31, 2008·British Journal of Haematology·Kenichi SawadaMakoto Hirokawa
Dec 11, 2008·European Journal of Haematology·Giovanni D'ArenaNicola Cascavilla

❮ Previous
Next ❯

Citations

May 18, 2012·TheScientificWorldJournal·Efthymia VlachakiIoannis Klonizakis
Mar 29, 2014·International Journal of Hematology·Alexander KanellopoulosTheodoros P Vassilakopoulos
Jun 18, 2011·Expert Opinion on Pharmacotherapy·Joanna Grabska, Constantin A Dasanu

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
biopsy
flow cytometry

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.