PMID: 9187483Jun 1, 1997Paper

Pure red cell aplasia during carbamazepine monotherapy

Brain & Development
T TagawaH Yamaguchi

Abstract

A 7-year-old girl developed pure red cell aplasia during carbamazepine (CBZ) monotherapy for epilepsy. She developed generalized clonic convulsions at the age of 7 years and 8 months. Treatment with CBZ was begun. Two months later she was admitted to our hospital because of severe anemia. Bone marrow examination revealed the almost complete absence of erythroblasts, with normal myelopoiesis and megakaryocytopoiesis, indicating pure red cell aplasia. Following the discontinuation of CBZ, she developed brisk reticulocytosis within 1 week and her hemoglobin level rose to a normal one within 1 month. Although the hematological toxicity of CBZ is well documented, isolated cessation of red cell production is uncommon. A patient who is undergoing treatment with CBZ should be carefully monitored, especially for serious adverse reactions including pure red cell aplasia.

References

Jul 1, 1989·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·K MaekawaN Imamura
Jan 1, 1987·Epilepsia·J M Pellock
Jul 15, 1974·JAMA : the Journal of the American Medical Association·Y G JeongG L River
Jan 1, 1982·JAMA : the Journal of the American Medical Association·L G MacDougall
Mar 1, 1982·Annals of Neurology·R G Hart, J D Easton
Nov 1, 1993·Southern Medical Journal·J SimmonsA Kaufman
Apr 1, 1993·British Journal of Haematology·S NikkariO Wanne
May 1, 1964·Archives of Internal Medicine·T E BRITTINGHAMD L MURPHY

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Citations

Apr 25, 2002·Journal of Pediatric Hematology/oncology·Gunnar SkeppnerGöran Elinder
Mar 28, 2007·Epilepsia·Gaetano ZaccaraEmilio Perucca
Jan 31, 2008·Acta Haematologica·Daniele FocosiMario Petrini
Mar 13, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A VerrottiG Coppola
Jul 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mario SuwalskyCarlos P Sotomayor
Jun 15, 2018·Expert Review of Clinical Pharmacology·Ingrid Fricke-GalindoMarisol López-López

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