Pure spinal multiple sclerosis: A possible novel entity within the multiple sclerosis disease spectrum

Multiple Sclerosis : Clinical and Laboratory Research
Jie Ping Schee, Shanthi Viswanathan

Abstract

We identified five female patients retrospectively with relapsing short-segment partial myelitis whose clinical and paraclinical features were suggestive of cord involvement of multiple sclerosis (MS)-type albeit not rigidly fulfilling the 2017 McDonald criteria. Notably, these patients had not developed any typical MS-like brain lesions despite repeated neuroimaging assessments over years. Comprehensive work-up for differential diagnoses of MS and other causes of transverse myelitis particularly neuromyelitis optica spectrum disorders had been consistently negative on longitudinal follow-up. Thus, we postulate a possible entity of pure spinal MS which may represent a novel forme fruste within the MS disease spectrum.

References

Dec 8, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Ju-Hong MinKwang Ho Lee
Feb 23, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Su-Hyun KimHo Jin Kim
Nov 29, 2012·Neurologic Clinics·Eoin P Flanagan, B Mark Keegan
Jan 15, 2014·Neurology·Douglas Kazutoshi SatoKazuo Fujihara
Oct 1, 2012·Multiple Sclerosis and Related Disorders·Dorlan J KimbroughUNKNOWN GJCF-CC&BR
Feb 20, 2015·Neurology·Ho Jin KimUNKNOWN Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen

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Citations

Feb 4, 2021·Journal of Clinical Medicine·Camilla OstiniChiara Zecca

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