PMID: 3748847Jan 1, 1986Paper

Purification and characterisation of VIP from two species of dogfish

Peptides
R Dimaline, M C Thorndyke

Abstract

Acid extracts of intestine from the dogfish Scyliorhinus canicula and Squalus acanthius were purified by gel filtration, ion exchange chromatography, and reversed-phase HPLC. In radioimmunoassays, VIP-like material from both species of dogfish cross reacted with N-terminal, but not C-terminal antisera. Like porcine VIP, both Scyliorhinus and Squalus VIP were stimulants of exocrine pancreatic secretion in the turkey. The time course of the responses to dogfish VIP were, however, different from that seen with porcine VIP. The present study has developed methods for the isolation of VIP-like peptides from elasmobranchs and has demonstrated that elasmobranch VIP differs from Porcine VIP in the C-terminal region, and that these differences may affect biological activity.

References

Jan 1, 1985·Peptides·M C Thorndyke, T J Shuttleworth
Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N W BunnettJ H Walsh
Jan 1, 1981·Cell and Tissue Research·A M BuchanA G Pearse
Jan 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M CarlquistV Mutt

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