PMID: 6983068Oct 1, 1982Paper

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver

Proceedings of the National Academy of Sciences of the United States of America
S CohenS T Sawyer

Abstract

We have purified the epidermal growth factor (EGF) receptor/protein kinase from the livers of normal mice by affinity chromatography. The biochemical properties of the liver receptor are very similar to those of the EGF receptor previously prepared from the human tumor cell line A-431 [Cohen, S., Ushiro, H., Stoscheck, C. & Chinkers, M. (1982) J. Biol. Chem. 257, 1523-1531]. The liver receptor for EGF is a glycoprotein of Mr 170,000. It binds 125I-labeled EGF and possesses an EGF-stimulable protein kinase activity specific for tyrosine residues. Both autophosphorylation and kinase activity toward exogenous substrates are demonstrable. The EGF receptor purified from normal mouse liver is antigenically related to the receptor purified from human A-431 cells.

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R N FabricantG J Todaro
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H HaiglerS Cohen
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Citations

Jan 1, 1985·Cell and Tissue Research·K A NaveM Schachner
Jan 1, 1986·The Journal of Membrane Biology·A M Soderquist, G Carpenter
Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·S Cohen
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May 1, 1984·Developmental Biology·E D Adamson, J Meek
Jul 1, 1984·Developmental Biology·B T LevyP F Maness
Dec 1, 1991·Developmental Biology·B Martineau-DoizéJ J Bergeron
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May 1, 1995·Cellular Signalling·I RamírezM Soley
Jul 13, 2012·Nature Reviews. Cancer·Yosef Yarden, Gur Pines
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P KahnT Graf
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y H XuI Pastan
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P Ghosh-DastidarC F Fox
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L BeguinotI Pastan
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S BishayeeC D Scher
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C A SchneiderH R Herschman
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T Ueda, D G Plagens
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y G YeungE R Stanley
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C I Bargmann, R A Weinberg
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R W Donaldson, S Cohen
Jan 1, 1988·The Journal of Cell Biology·L W Jiang, M Schindler
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Jan 5, 2011·Chinese Journal of Cancer·Jill WykoskyWebster K Cavenee
Jul 1, 1983·Molecular and Cellular Endocrinology·G Carpenter
Nov 17, 2009·Advanced Drug Delivery Reviews·Chitta Ranjan PatraPriyabrata Mukherjee
Oct 31, 1983·Biochemical and Biophysical Research Communications·L J DangottM H Melner

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