Purification and properties of peptides which induce germination of blastospores of Candida albicans

Journal of General Microbiology
F W ChattawayJ O'Reilly

Abstract

A glycopeptide and a peptide have been isolated from bovine seminal plasma which together will induce germination of Candida albicans blastospores at 37 degrees C and in the presence of glucose and Mn2+. ¿They have molecular weights of 2000 to 3000. Both peptides contain appreciable amounts of aspartic and glutamic acids, only the glycopeptide contains threonine, lysine, histidine and arginine, while only the peptide contains proline. Acid hydrolysates are fully active in inducing germination and a mixture of aspartic acid, lysine, histidine, threonine, proline and beta-alanine can replace them. Mn2+ is not then required. Amino acid mixtures are required to be present throughout the whole period in the incubation medium for full germination to take place, but the peptides can be removed after 1 h incubation and if the cells are resuspended in a buffered glucose medium full germination occurs after a further 3 h incubation.

Citations

Jan 1, 1984·Critical Reviews in Microbiology·G San-Blas, F San-Blas
Feb 11, 2015·Applied and Environmental Microbiology·Francisco J AlvarezPer O Ljungdahl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.