PMID: 6794566Aug 1, 1981

Purification and properties of two distinct groups of ADH isozymes from Chinese hamster liver

Biochemical Genetics
B G TalbotJ P Thirion

Abstract

Two major classes of alcohol dehydrogenase isozymes have been purified from Chinese hamster liver. The two isozyme classes have the same subunit molecular weights but different electrophoretic mobilities. They have a similar range of substrates but different KROM values and sensitivities to the inhibitor pyrazole. The ADHs are immunologically related as determined by Ouchterlony double diffusion experiments. These results suggest that the isozymes are encoded by different structural gene loci derived from a common ancestral gene.

References

Nov 1, 1975·Archives of Biochemistry and Biophysics·A I CederbaumE Rubin
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T K LiB L Vallee
Apr 1, 1979·Alcoholism, Clinical and Experimental Research·J D Hempel, R Pietruszko
Dec 28, 1979·Biochemical and Biophysical Research Communications·W F BosronB L Vallee
Mar 1, 1976·The Biochemical Journal·R J DuncanL Sokoloff
Jan 10, 1977·Biochemical and Biophysical Research Communications·W F Borson, T K Li
Jul 1, 1976·Biophysical Chemistry·R CohenC Soulie
Mar 3, 1975·Biochemical and Biophysical Research Communications·T K Li, L J Magnes
Sep 1, 1970·European Journal of Biochemistry·Hans Jörnvall
Feb 1, 1971·Annals of Human Genetics·M SmithH Harris
Apr 1, 1969·Archives of Biochemistry and Biophysics·R Pietruszko, H Theorell

Related Concepts

Alcohol Oxidoreductases
Metazoa
Cricetulus
Immunodiffusion Measurement
Cistron
Cricetus
Alloenzymes
Liver
Substrate Specificity
Macromolecular Compounds

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