PMID: 5914761Oct 14, 1966

Purification and reconstitution of the periodic fibril and unit structure of human amyloid

Science
G G Glenner, H A Bladen

Abstract

Extraction with alkaline sodium glycinate of the periodic fibril and unit structure of human amyloid and subsequent acidification of the extract provided a method for the purification as well as for the reconstitution of the periodic rod and of the unit structure. Guanidine completely solubilized and irreversibly dissociated both the rod and the unit structure of the human amyloid fibril.

Citations

Jun 1, 1994·Microscopy Research and Technique·H J Merker
Nov 1, 1967·The Journal of Cell Biology·T Shirahama, A S COHEN
Jul 1, 1988·Stain Technology·M T Elghetany, A Saleem
Nov 17, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Manuel Menendez-GonzalezRenee Ribacoba
Nov 1, 1969·Journal of Ultrastructure Research·S Hirschl
Feb 21, 1967·Biochemical and Biophysical Research Communications·P Mueller, D O Rudin
Jan 29, 1986·Biochemical and Biophysical Research Communications·S InoueA S COHEN
Mar 17, 2018·Biochemistry. Biokhimii︠a︡·O V GalzitskayaO M Selivanova

Related Concepts

Amyloid Fibrils
Electrophoresis
Glycine, Sodium Hydrogen Carbonate
Guanidines
Electron Microscopy
Myocardium
Spleen
Ultracentrifugation

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