Purification and structural analyses of ABCG2.

Advanced Drug Delivery Reviews
Christopher A McDevittR Callaghan

Abstract

ABCG2 is best known as a multidrug transporter capable of conferring resistance to cancer cells. However, the protein is also inherently expressed in numerous barrier tissues and intriguingly within hematopoietic stem cells. Unlike its partners ABCB1 and ABCC1, there is considerably less information available on the molecular mechanism of ABCG2. The transporter has a distinct topology and is presumed to function as a homodimer. However, a number of biochemical studies have presented data to suggest that the protein adopts higher order oligomers. This review focuses on this controversial issue with particular reference to findings from low resolution structural data. In addition, a number of molecular models of ABCG2 based on high resolution structures of bacterial ABC transporters have recently become available and are critically assessed. ABCG2 is a structurally distinct member of the triumvirate of human multidrug transporters and continues to evade description of a unifying molecular mechanism.

References

Jan 10, 1998·The Journal of Biological Chemistry·X B ChangJ R Riordan
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Jul 5, 2001·Biochemical and Biophysical Research Communications·C OzvegyB Sarkadi
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Kumie KageYoshikazu Sugimoto
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Joachim Frank
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sheng ZhouBrian P Sorrentino
Apr 2, 2003·The Journal of Biological Chemistry·Tavan JanvilisriHendrik W van Veen
Sep 2, 2003·Trends in Biotechnology·Pascal Braun, Josh LaBaer
Jun 13, 1959·Nature·J PORATH, P FLODIN
Sep 25, 2003·The Journal of Biological Chemistry·Gregory A GrafHelen H Hobbs
Oct 7, 2003·Molecular Cell·Jue ChenFlorante A Quiocho
Dec 20, 2003·Nature·Henrietta VenterHendrik W Van Veen
Mar 6, 2004·The Journal of Biological Chemistry·Junkang XuJian-Ting Zhang
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
Jul 9, 2004·Biochemical and Biophysical Research Communications·Qingcheng MaoJashvant D Unadkat
Jul 21, 2004·Biochemistry·Orsolya PolgarSusan E Bates
Nov 24, 2004·Pharmaceutical Research·Chihiro KondoYuichi Sugiyama
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Toshihisa IshikawaYasuhiro Sumino
Apr 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tappei TakadaYuichi Sugiyama
Aug 19, 2005·The Journal of Biological Chemistry·Olivier DalmasJean-Michel Jault
Aug 19, 2005·The Journal of Biological Chemistry·Ulla HenriksenUlrik Gether
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·P Krishnamurthy, J D Schuetz
Jul 4, 2006·Protein Science : a Publication of the Protein Society·Karin F K EjendalChristine A Hrycyna
Jul 19, 2006·Cellular and Molecular Life Sciences : CMLS·A PozzaA Di Pietro
Sep 19, 2006·British Journal of Pharmacology·R ClarkR Callaghan
Nov 14, 2006·Structure·Christopher A McDevittRichard Callaghan
Jan 26, 2007·Biochemical and Biophysical Research Communications·Mara L Leimanis, Elias Georges

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Citations

Mar 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Owen M WoodwardWilliam B Guggino
Jun 23, 2012·PLoS Neglected Tropical Diseases·Christopher KayIan D Kerr
Sep 30, 2010·Expert Opinion on Drug Metabolism & Toxicology·Maren PoguntkeOliver Zolk
Jul 19, 2014·Drug Metabolism Reviews·Milena Julia SzafraniecLeszek Fiedor
Sep 17, 2013·Biochimica Et Biophysica Acta·Naomi L PollockRichard Callaghan
Aug 4, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Simon N GoslingNigel W Arnell
Sep 1, 2017·Pharmacogenetics and Genomics·Alison E FohnerTeri E Klein
Jun 11, 2016·Biochemical Society Transactions·Aaron J HorseyIan D Kerr
Oct 6, 2020·FEBS Letters·Balázs SarkadiTamás Hegedűs
Apr 4, 2021·International Journal of Molecular Sciences·László Homolya
Aug 5, 2018·Journal of Medicinal Chemistry·Michael K KrapfMichael Wiese

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