PMID: 1060093Oct 1, 1975

Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxis

Proceedings of the National Academy of Sciences of the United States of America
E J Goetzl, K F Austen

Abstract

Preferential eosinophil chemotactic activity exhibiting a molecular weight comparable to that released from sensitized human lung fragments challenged with specific antigen and designated eosinophil chemotactic factor of anaphylaxis has been isolated from extracts of human lung fragments by sequential purification on Sephadex G-25, Dowex-1, Sephadex G-10, and paper chromatography. Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu were recovered from the extracts in 4-12% overall yield of the low molecular weight peak from Sephadex G-25. Purified eosinophil chemotactic factor of anaphylaxis and the synthetic tetrapeptides were maximally active in amounts from 0.1 to 1.0 nmol per chemotactic chamber, and the activity was dependent on both the NH2-terminal and the COOH-terminal residues. Both natural and synthetic peptides were preferentially chemotactic for eosinophils and rendered them unresponsive to a subsequent stimulus.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E SchiffmannS M Wahl
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
Aug 9, 1973·The New England Journal of Medicine·M KalinerK F Austen
Dec 1, 1972·The Journal of Experimental Medicine·E J Goetzl, K F Austen
Feb 21, 1974·The New England Journal of Medicine·S I WassermanK F Austen
Jan 4, 1966·Biochemical and Biophysical Research Communications·H MatsuoT Tatsuno
Feb 21, 1967·Biochimica Et Biophysica Acta·K R Woods, K T Wang

Citations

Jan 1, 1983·Archives of Dermatological Research·B M CzarnetzkiP C Frei
Sep 1, 1983·Inflammation·S Wescott, M Kaliner
Jan 1, 1992·Veterinary Research Communications·B J McEwen
Jun 1, 1981·Springer Seminars in Immunopathology·B U Wintroub, N A Soter
Jun 1, 1981·Springer Seminars in Immunopathology·B U Wintroub, M C Mihm
Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Mar 7, 1980·European Journal of Pharmacology·Z HorakovaM A Beaven
Nov 1, 1980·The Journal of Allergy and Clinical Immunology·N A Soter, S I Wasserman
Dec 1, 1988·The Journal of Allergy and Clinical Immunology·U PipkornL Enerbäck
May 22, 1980·Biochimica Et Biophysica Acta·S K AckermanS D Douglas
Feb 23, 1978·The New England Journal of Medicine·B U WintroubK F Austen
May 1, 1978·The Journal of Cell Biology·S H Zigmond
Jun 1, 1983·The Journal of Experimental Medicine·M C O'DonnellL L Thomas
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·W E Brocklehurst
Sep 1, 1989·The American Review of Respiratory Disease·U PipkornL Enerbäck
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·P BalukD M McDonald
Jun 1, 1980·The Journal of Clinical Investigation·D A BassC E McCall
Dec 1, 1986·The Journal of Clinical Investigation·A J WardlawA B Kay
Nov 1, 1987·The Journal of Clinical Investigation·T B CasaleG W Hunninghake
Apr 1, 1980·Environmental Health Perspectives·S I Wasserman
Apr 1, 1984·Environmental Health Perspectives·S I Wasserman
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I IwamotoS Yoshida
Feb 1, 1983·Experimental Lung Research·D Lagunoff
Apr 1, 1990·Gastroenterology·L E LeDuc, C C Nast
Jan 1, 1980·The British Journal of Dermatology·U DierksmeierB M Czarnetzki
Dec 1, 1976·The Journal of Allergy and Clinical Immunology·R A ClarkA P Kaplan
Sep 26, 2000·Pulmonary Pharmacology & Therapeutics·M A GiembyczM A Lindsay
Jun 1, 1989·Scandinavian Journal of Immunology·E MoritaE Christophers
Jul 1, 1987·Allergy·A J Wardlaw, A B Kay
Jan 1, 1980·International Journal of Dermatology·S I Wasserman
Apr 1, 1980·International Journal of Dermatology·S C Whited, J I Gallin
Sep 1, 1983·International Journal of Dermatology·R F Lemanske, M A Kaliner
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H OgawaP A Ward
Jul 1, 1983·The Journal of Pathology·H W Steer, D A Lewis
Jan 1, 1982·Equine Veterinary Journal·C J HannaD G McBeath
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·M Tavassoli
Jul 1, 1992·Scandinavian Journal of Gastroenterology·H S Kim, A Berstad
Sep 1, 1978·CRC Critical Reviews in Toxicology·M N Walters, J M Papadimitriou
Mar 1, 1988·Digestive Diseases and Sciences·C C Nast, L E LeDuc
Apr 1, 1985·International Journal of Peptide and Protein Research·G R BeilharzP E Wright
Dec 1, 1985·European Journal of Immunology·M VeithA Capron
Jan 1, 1980·Infection·R R Kretschmer, M L Collado
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·C H Kirkpatrick
Nov 1, 1986·Immunological Investigations·E L MorganW O Weigle
Jan 1, 1976·Immunological Communications·R N BoswellE J Goetzl
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·O E AldreyN E Bianco
Jan 1, 1988·Pediatric Pulmonology·W M Abraham, A Wanner
Jul 30, 2019·Frontiers in Endocrinology·Marcelo G KazanietzMariana Cooke

Related Concepts

Anaphylaxis
Chemotaxis
Eosinophil
Lung
Oligopeptides

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.