PMID: 9643472Jun 27, 1998Paper

Purification of a 5-HT uptake inhibitor from the venom of Cerastes vipera

Toxicon : Official Journal of the International Society on Toxinology
M AlzahabyE G Rowan

Abstract

A protein that inhibits the re-uptake of 5-hydroxytryptamine into rat brain synaptosomes was isolated from the venom of the Sahara sand viper (Cerastes vipera) by gel filtration and reverse phase chromatography. It has a molecular weight of 13,739 Da and an IC50 of about 50 nM for blocking uptake of 3H-5-HT into rat brain synaptosomes. It also augmented the responses to 5-HT in a smooth muscle preparation. It has phospholipase A2 activity, but it has no lytic activity as measured by its inability to release lactate dehydrogenase from rat brain synaptosomes. Determination of the N-terminal sequence revealed a similarity with a phospholipase A2 previously isolated from Cerastes cerastes venom.

References

Dec 1, 1992·Analytical Biochemistry·D C Brune
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·F L Djebari, M F Martin-Eauclaire
Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·R S LabibN W Farag
Apr 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·M C TzengC M Dupureur
Aug 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·T FaridM F el-Asmar
Jul 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·B FrancisI I Kaiser
Oct 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·M AlzahabyA L Harvey

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Citations

May 15, 2002·Trends in Pharmacological Sciences·Alan L Harvey

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