Purification of dendritic cell and macrophage subsets from the normal mouse small intestine

Journal of Immunological Methods
Balázs KoscsóMilena Bogunovic

Abstract

Mononuclear phagocytes are essential for protecting against pathogens breaching the intestinal mucosa and maintaining the integrity of the gastrointestinal tract. The mononuclear phagocyte family of the healthy intestine is represented by a small population of hematopoietic cells including dendritic cells and macrophages. Distinct mononuclear phagocyte subsets strategically accumulate within and below the mucosal epithelium and are distributed in the submucosa and muscularis externa. Shaped by its unique microenvironment, each mononuclear phagocyte subset is developmentally and functionally unique and phenotypically distinct. Here we summarize our recent advances on identifying and purifying various intestinal mononuclear phagocyte subsets by flow cytometry in the context of their developmental properties and location within the intestinal tissue.

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Citations

Dec 27, 2015·Journal of Immunological Methods·Balázs KoscsóMilena Bogunovic
Nov 4, 2015·Frontiers in Cellular Neuroscience·Simon VerheijdenGuy E Boeckxstaens
Aug 19, 2015·Cell Reports·Casandra PaneaIvaylo I Ivanov
Jun 13, 2016·Trends in Immunology·Kara Gross MargolisMilena Bogunovic
Jul 30, 2016·Mediators of Inflammation·Claudio BernardazziHeitor Siffert P de Souza
Aug 2, 2016·Current Protocols in Immunology·Balázs Koscsó, Milena Bogunovic
Oct 26, 2018·Science Translational Medicine·Nicholas A ScottElizabeth R Mann
Feb 27, 2017·Pflügers Archiv : European journal of physiology·Sven Wehner, Daniel Robert Engel
Apr 12, 2020·Science Immunology·Balázs KoscsóMilena Bogunovic
Apr 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Marina AvetisyanRobert O Heuckeroth
May 28, 2019·Microbiology Spectrum·Sarah E F D'Orazio

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