PMID: 1212663Dec 1, 1975Paper

Purification of tumor-specific antigens. An overview of the relevance to human colon carcinoma

Cancer
B D KahanN R Pellis

Abstract

Methods which dissociate intramolecular noncovalent bonds have been used to prepare soluble derivatives of cell-surface antigens. Applications of these techniques to human colon carcinoma are underway. Continuous tissue-culture strains derived from primary lesions were developed and shown to be composed of malignant epithelial elements. Parallel data on the preparation and activity of soluble materials in a murine model methylcholanthrene system reveal that although cultured cells are a satisfactory source for antigen extraction, they are poor targets of the immune response. The development of methods to quantitate the biologic activity of colon-specific, soluble materials may provide indicator systems to define the antigenic determinants, to permit purification, and to serve as assays of the efficacy of immunotherapy.

References

Mar 1, 1975·The Journal of Surgical Research·B D Kahan, N R Pellis
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Jan 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·B D KAHAN

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Citations

May 1, 1983·The Journal of Urology·R P HubenJ E Pontes
Apr 1, 1977·La Ricerca in Clinica E in Laboratorio·R W Baldwin, M R Price

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