Purified Protein Derivative Skin test prior to bacillus Calmette-Guérin Therapy May have Therapeutic Impact in Patients with Nonmuscle Invasive Bladder Cancer

The Journal of Urology
Naoya NiwaMototsugu Oya

Abstract

We investigated the clinical impact of the purified protein derivative skin test prior to bacillus Calmette-Guérin therapy in patients with nonmuscle invasive bladder cancer treated with adjuvant bacillus Calmette-Guérin therapy. A total of 498 patients with nonmuscle invasive bladder cancer treated with adjuvant bacillus Calmette-Guérin were included in study, of whom 320 underwent the purified protein derivative skin test 1 to 2 weeks prior to therapy. Oncologic outcomes and the rate of bacillus Calmette-Guérin related side effects were statistically evaluated. The mean ± SD 5-year recurrence-free survival rate in patients who did vs did not undergo the purified protein derivative skin test was 66.6% ± 2.8% and 59.1% ± 4.1%, respectively, which was significantly different (p = 0.048). No significant difference was observed in the progression-free survival rate between patients who did vs did not undergo the test. Multivariate Cox regression analysis revealed that a history of recurrence (HR 1.59, p = 0.02), multiple tumors (HR 1.95, p <0.01), the bacillus Calmette-Guérin Connaught strain (HR 0.71, p = 0.04), 7 or more bacillus Calmette-Guérin instillations (HR 0.70, p = 0.04) and undergoing the purified protein derivative ski...Continue Reading

References

Mar 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R A BadalamentH F Oettgen
Nov 1, 1982·The Journal of Urology·D L LammH M Radwin
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·D Menzies
May 21, 1999·Lancet·A B AlexandroffK James
Mar 10, 2009·Seminars in Immunology·Megan K L MacLeodPhilippa Marrack
Apr 27, 2012·Seminars in Immunopathology·Shuo-Wang QiaoLudvig M Sollid
Jun 8, 2012·Science Translational Medicine·Claire BiotMatthew L Albert
Feb 5, 2014·Nature Reviews. Urology·Gil Redelman-SidiBernard H Bochner
Jun 19, 2016·The Journal of Urology·Sam S ChangJames M McKiernan
Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner
Oct 5, 2016·Journal of the National Comprehensive Cancer Network : JNCCN·Peter E ClarkCourtney Smith

❮ Previous
Next ❯

Citations

Oct 30, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Hiroshi Fukushima, Yasuhisa Fujii
Jul 18, 2020·Nature Reviews. Urology·Jelmer H van PuffelenSita H Vermeulen
Dec 3, 2020·Urologic Oncology·John P SfakianosAmir Horowitz

❮ Previous
Next ❯