Purified thromboplastin causes haemostatic abnormalities but not overt DIC in an experimental rabbit model

Thrombosis Research
Line Olrik BerthelsenM Tranholm

Abstract

Validation of animal models of disseminated intravascular coagulation (DIC) to human DIC is crucial in order to translate findings in research models to treatment modalities for DIC in humans. ISTH classifications of overt and non-overt human DIC have proven to have a high diagnostic accuracy, and we have previously established a rabbit model of non-overt DIC based on the ISTH classification of non-overt DIC. In this rabbit model, we used purified rabbit brain thromboplastin to induce DIC and test applicability of ISTH classifications of overt human DIC. Cardiovascular and haematological parameters from rabbits, either saline-injected or administered a 2.5 mg thromboplastin/kg bolus and a 15 minutes 1.25 mg thromboplastin/kg infusion, were determined at four time points over a 90 minute period. All groups of rabbits were scored at each time point according to the ISTH classifications of overt DIC. Despite the fact that injection of purified thromboplastin resulted in decreased platelet count, increased prothrombin time, activated partial thromboplastin time, level of thrombin-antithrombin complexes and fibrin degradation products, and pulmonary micro-thrombosis, none of the rabbits were diagnosed as having overt DIC according t...Continue Reading

References

Sep 11, 2001·Acta Haematologica·M B Donati, A Falanga
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rodger L Bick
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hidesaku AsakuraShinji Nakao
Oct 3, 2006·Expert Review of Molecular Diagnostics·Peter James O'Brien
Nov 14, 2006·Journal of Thrombosis and Haemostasis : JTH·C H TohUNKNOWN SSC on Disseminated Intravascular Coagulation of the ISTH
Mar 19, 2008·Journal of Veterinary Internal Medicine·B WiinbergA T Kristensen
Sep 4, 2008·Thrombosis and Haemostasis·Jolanta M Siller-MatulaBernd Jilma
Oct 14, 2008·The Journal of Trauma·John R HessBertil Bouillon
Jun 16, 2009·Thrombosis Research·Line Olrik BerthelsenMikael Tranholm

❮ Previous
Next ❯

Citations

Jan 16, 2016·Journal of Avian Medicine and Surgery·Sophie StrindbergMads F Bertelsen
Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Tracy Stokol
Oct 8, 2011·Thrombosis and Haemostasis·Jolanta M Siller-MatulaBernd Jilma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.