Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis.

Cancer Letters
Iain L O BuxtonRobert M Matz

Abstract

Several advances have recently expanded models of tumor growth and promoted the concept of tumor homeostasis, the hypothesis that primary tumors exert an anti-proliferative effect on both themselves and subclinical secondary metastases. Recent trials indicate that the characterization of tumor growth as uncontrolled is inconsistent with animal models, clinical models, and epidemiological models. There is a growing body of evidence which lends support to an updated concept of tumor growth: tumor homeostasis. In the case of breast cancer, if not all metastasizing tumors, these advances suggest an inconvenient truth. That is, if breast tumor cells metastasize to distant sites early in the tumorigenesis process, then removal of a breast tumor may hasten the development of its metastases. We explore the heretofore unappreciated notion that nucleotides generated by tumor cells following the secretion of an ADP-kinase can promote metastasis and support angiogenesis. Evidence is presented that blockade of the actions of nucleotides in the setting of newly diagnosed breast cancer may provide a useful adjunct to current anti-angiogenesis treatment.

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Citations

Jun 26, 2013·Purinergic Signalling·Geoffrey Burnstock, Francesco Di Virgilio
Feb 26, 2014·Journal of Mammary Gland Biology and Neoplasia·Nicolas MontalbettiMatthias A Hediger
Sep 24, 2011·Advances in Hematology·Junko Okabe-KadoYasuhiko Kaneko
Feb 20, 2014·FEBS Letters·Alexander W Lohman, Brant E Isakson
Nov 25, 2014·Critical Reviews in Biochemistry and Molecular Biology·Gennady G Yegutkin
Apr 1, 2015·International Journal of Oncology·Vincent BlanckaertBenoît Chénais
Apr 10, 2012·Seminars in Cancer Biology·Daniela SpanoMassimo Zollo
Nov 18, 2011·Cancers·Iain L O Buxton, Nucharee Yokdang
Oct 26, 2010·Chronobiology International·Bernardo Carraro DetanicoIraci Lucena da Silva Torres
Dec 29, 2020·Frontiers in Pharmacology·Victor Manuel Ruiz-RodríguezDiana Patricia Portales-Pérez
Dec 20, 2020·Biochemical Pharmacology·Gennady G Yegutkin
Feb 13, 2021·Purinergic Signalling·Julia Beatrice de AraújoDébora Tavares de Resende E Silva

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