Purinergic P2X7 receptor functional genetic polymorphisms are associated with the susceptibility to osteoporosis in Chinese postmenopausal women

Purinergic Signalling
Hong XuShangdong Liang

Abstract

Osteoporosis (OP) is a major public health problem worldwide. Genetic factors are considered to be major contributors to the pathogenesis of OP. The purinergic P2X7 receptor (P2X7R) has been shown to play a role in the regulation of osteoblast and osteoclast activity and has been considered as an important candidate gene for OP. A case-control study was performed to investigate the associations of functional single nucleotide polymorphisms (SNPs) in the P2X7R gene (rs2393799, rs7958311, rs1718119, rs2230911, and rs3751143) with susceptibility to OP in 400 Chinese OP patients and 400 controls. Results showed that rs3751143 was associated with OP; in particular, carriers of the C allele and CC/(AC + CC) genotypes were at a higher risk of OP, but no significant association of rs2230911, rs7958311, rs1718119, and rs2393799 with OP risk was observed. Analysis of the haplotypes revealed one haplotype (rs1718119G-rs2230911G-rs3751143C) that appeared to be a significant "risk" haplotype with OP. The rs3751143 polymorphism was associated with osteoclast apoptosis; ATP-induced caspase-1 activity of osteoclasts with AC and CC genotypes is lower than that of osteoclasts with AA genotype in vitro. The findings suggest that the P2X7R rs37511...Continue Reading

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Citations

Oct 15, 2018·Journal of Cellular Physiology·Dehui ZengHong Zhao
May 14, 2019·Climacteric : the Journal of the International Menopause Society·W XiaoH Xu
Aug 15, 2019·Molecular Genetics and Genomics : MGG·Tao PengChang Sun
Nov 20, 2021·Frontiers in Genetics·Rebeka da Conceição SouzaAlba Lucínia Peixoto-Rangel

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Methods Mentioned

BETA
X-Ray
Genotyping
PCR
electrophoresis

Software Mentioned

SPSS
Haploview
Plink
SHEsis
MEDILINK

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