Purinergic regulation of sound transduction and auditory neurotransmission

Audiology & Neuro-otology
G D HousleyP R Thorne

Abstract

In the cochlea, extracellular ATP influences the endocochlear potential, micromechanics, and neurotransmission via P2 receptors. Evidence for this arises from studies demonstrating widespread expression of ATP-gated ion channels (assembled from P2X receptor subunits) and G protein-coupled receptors (P2Y receptors). P2X2 receptor subunits are localized to the luminal membranes of epithelial cells and hair cells lining scala media. These ion channels provide a shunt pathway for K+ ion egress. Thus, when noise exposure elevates ATP levels in this cochlear compartment, the K+ conductance through P2X receptors reduces the endocochlear potential. ATP-mediated K+ efflux from scala media is complemented by a P2Y receptor G protein-coupled pathway that provides coincident reduction of K+ transport into scala media from the stria vascularis when autocrine or paracrine ATP signalling is invoked. This purinergic signalling likely provides a basis for a reactive homoeostatic regulatory mechanism limiting cochlear sensitivity under stressor conditions. Elevation of ATP in the perilymphatic compartment under such conditions is also likely to invoke purinergic receptor-mediated changes in supporting cell micromechanics, mediated by Ca2+ influx...Continue Reading

Citations

Jun 15, 2006·The Journal of Membrane Biology·G D HousleyE N Yamoah
Jun 15, 2006·The Journal of Membrane Biology·D DulonR L Davis
Dec 6, 2005·Cell and Tissue Research·Marina F BystrovaStanislav S Kolesnikov
Feb 8, 2007·Cell and Tissue Research·Srdjan M VlajkovicPeter R Thorne
Feb 21, 2004·Journal of the Association for Research in Otolaryngology : JARO·Peter R ThorneGary D Housley
Mar 28, 2008·Purinergic Signalling·Erik M Schwiebert, J Gregory Fitz
Mar 21, 2009·Purinergic Signalling·Helle A Praetorius, Jens Leipziger
Sep 2, 2010·Purinergic Signalling·Narinobu Harada
Sep 2, 2010·Purinergic Signalling·Paromita MajumderFabio Mammano
Sep 2, 2010·Purinergic Signalling·Ravindra S TelangPeter R Thorne
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fabio AnselmiFabio Mammano
Jul 21, 2009·Clinical and Experimental Pharmacology & Physiology·Donald Robertson
Oct 15, 2008·Annual Review of Physiology·Annmarie Surprenant, R Alan North
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Denise YanXue Z Liu
Dec 18, 2013·Seminars in Pediatric Neurology·Agustín LegidoMichael J Goldenthal
Sep 16, 2008·Hearing Research·Kevin K Ohlemiller
Mar 16, 2007·Brain Research·Shujiro B MinamiJosef M Miller
Jun 3, 2016·Frontiers in Physiology·Rahul MittalXue Z Liu
Mar 11, 2009·Neuroscience·M A CrumlingR K Duncan
Mar 1, 2005·The Journal of Comparative Neurology·Lin-Chien HuangGary D Housley
Jul 3, 2009·Journal of Neurophysiology·Ivan MilenkovicRudolf Rübsamen
May 3, 2019·Journal of Neurophysiology·Margarete A Ueberfuhr, Markus Drexl
Oct 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Benjamin GeorgeMufeng Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.