Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells.

Frontiers in Endocrinology
Miguel Martin-Aragon BaudelManuel F Navedo

Abstract

The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity. Accordingly, purinergic receptor actions, acting as either ion channels (P2X) or G protein-coupled receptors (GCPRs) (P1, P2Y), target diverse downstream effectors, and substrates to regulate vascular smooth muscle function and vascular reactivity. Both vasorelaxant and vasoconstrictive effects have been shown to be mediated by different purinergic receptors in a vascular bed- and species-specific manner. Purinergic signaling has been shown to play a key role in altering vascular smooth muscle excitability and vascular reactivity following acute and short-term elevations in extracellular glucose (e.g., hyperglycemia). Moreover, there is evidence that vascular smooth muscle excitability and vascular reactivity is severely impaired during diabetes and that this is mediated, at least in part, by activation of purinergic receptors. Thus, purinergic receptors present themselves as important candidates mediating vascular reactivity in hyperglycemia, with potentially important clinical and therapeutic potential. In thi...Continue Reading

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Citations

Oct 22, 2020·Nature Communications·Maria Paz PradaMadeline Nieves-Cintrón
May 15, 2021·International Journal of General Medicine·Yanhui TangYu Ling
Aug 8, 2021·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina

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Methods Mentioned

BETA
nuclear translocation
biosensors
biosensor
proximity ligation assay

Software Mentioned

MA

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