Purinergic Signaling in Endometriosis-Associated Pain.

International Journal of Molecular Sciences
Carla Trapero, Mireia Martín-Satué

Abstract

Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease. This review is intended to exhaustively gather current knowledge on purinergic signaling in endometriosis-associated pain. Altered extracellular ATP hydrolysis, due to changes in ectonucleotidase activity, has been reported in endometriosis; the resulting accumulation of ATP in the endometriotic microenvironment points to sustained activation of nucleotide receptors (P2 receptors) capable of generating a persistent pain message. P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and is enrolled in endometriosis-related pain. Pharmacological inhibition of P2X3 receptor is under evaluation as a pain relief treatment for women with endometriosis. The role of other ATP receptors is also discussed here, e.g., P2X4 and P2X7 receptors, which are involved in inflammatory cell-nerve and microglia-nerve crosstalk, and therefore in inflammatory and neuropathic pain. Adenosine receptors (P1 r...Continue Reading

References

Mar 17, 1999·British Journal of Pharmacology·S UenoK Inoue
Jul 2, 2003·Cellular Signalling·Gunnar Schulte, Bertil B Fredholm
Jul 5, 2003·Molecular and Cellular Biochemistry·Emerson André CasaliJoão José Freitas Sarkis
Sep 1, 2005·Cellular and Molecular Neurobiology·Srihasam Lakshmi, Preeti G Joshi
Aug 8, 2006·American Journal of Obstetrics and Gynecology·Mauro BusaccaFabio Parazzini
Sep 5, 2006·Human Reproduction·Natsuko TokushigeIan S Fraser
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anna K ClarkMarzia Malcangio
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lauriane UlmannFrancois Rassendren
Jan 7, 2009·Histochemistry and Cell Biology·M Martín-SatuéJean Sévigny
Jan 20, 2009·Human Reproduction·Guoyun WangIan S Fraser
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna K ClarkMarzia Malcangio
Jul 25, 2009·Medical Hypotheses·Geoffrey Burnstock
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa C LoramLinda R Watkins
Dec 4, 2009·Human Reproduction·Xinmei ZhangCaiyun Zhou
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaowei ChenG F Gebhart
Feb 16, 2010·Fertility and Sterility·Natsuko TokushigeIan S Fraser
Jun 1, 2010·Nature Neuroscience·Nanna GoldmanMaiken Nedergaard
Jun 22, 2010·The EMBO Journal·Lauriane UlmannFrançois Rassendren
Jun 25, 2010·Journal of Assisted Reproduction and Genetics·Carlo BullettiAndrea Borini
Jul 24, 2010·American Journal of Hematology·Michael BennettPhilippe Gaulard
Nov 3, 2010·Pain·Jana Sawynok
Jan 18, 2011·Trends in Molecular Medicine·Mark J Zylka
May 19, 2011·Advances in Pharmacology·Igor Feoktistov, Italo Biaggioni
Jun 16, 2011·Human Reproduction Update·K E MayC M Becker
Sep 6, 2011·Brain, Behavior, and Immunity·Julia ArnoldSylvia Mechsner
May 5, 2012·Purinergic Signalling·Herbert ZimmermannNorbert Sträter

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination

Clinical Trials Mentioned

NCT01432730
NCT02502097
NCT02477709
NCT03654326
NCT00376454
NCT00452777
NCT01034306
NCT01265667
NCT00790673
NCT02128958

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Handbook of Experimental Pharmacology
J Sawynok
Journal of Minimally Invasive Gynecology
Fred M Howard
Current Opinion in Investigational Drugs
Xue Jun Liu, Michael W Salter
© 2021 Meta ULC. All rights reserved