Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder

Frontiers in Physiology
D LindbergDoo-Sup Choi

Abstract

Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep. Moreover, ethanol has been demonstrated to disrupt purinergic signaling, while dysfunction of the purinergic system has been implicated in conditions of drug abuse such as AUD. In this review, we summarize our current knowledge regarding circadian disruption by ethanol, focusing on the reciprocal relationship that exists between oscillatory neurotransmission and the molecular circadian clock. In particular, we offer detailed explanations and hypotheses regarding the concerted regulation of purinergic signaling and circadian oscillations by neurons and astrocytes, and review the diverse mechanisms by which purinergic dysfuction may contrib...Continue Reading

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Citations

Jul 31, 2019·Journal of Neurochemistry·Dietrich van CalkerTsvetan Serchov
Jan 26, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Hao WangJing-Song Xu
Jun 21, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey J Moffat, Dorit Ron
Jan 15, 2021·Pharmacology, Biochemistry, and Behavior·Eduardo K TamuraNatalí N Guerrero-Vargas
Jul 12, 2020·Biochimica Et Biophysica Acta. Biomembranes·Nao HasuzawaMasatoshi Nomura

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Methods Mentioned

BETA
genetic knockout

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