Purinergic signaling in scarring

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Davide FerrariBruce N Cronstein

Abstract

Adenosine (ADO) and nucleotides such as ATP, ADP, and uridine 5'-triphosphate (UTP), among others, may serve as extracellular signaling molecules. These mediators activate specific cell-surface receptors-namely, purinergic 1 and 2 (P1 and P2)-to modulate crucial pathophysiological responses. Regulation of this process is maintained by nucleoside and nucleotide transporters, as well as the ectonucleotidases ectonucleoside triphosphate diphosphohydrolase [ENTPD; cluster of differentiation (CD)39] and ecto-5'-nucleotidase (5'-NT; CD73), among others. Cells involved in tissue repair, healing, and scarring respond to both ADO and ATP. Our recent investigations have shown that modulation of purinergic signaling regulates matrix deposition during tissue repair and fibrosis in several organs. Cells release adenine nucleotides into the extracellular space, where these mediators are converted by CD39 and CD73 into ADO, which is anti-inflammatory in the short term but may also promote dermal, heart, liver, and lung fibrosis with repetitive signaling under defined circumstances. Extracellular ATP stimulates cardiac fibroblast proliferation, lung inflammation, and fibrosis. P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have...Continue Reading

References

Feb 1, 1997·Clinical Science·R AlcoladoJ P Iredale
Mar 1, 1997·Trends in Pharmacological Sciences·B B FredholmM Williams
Sep 9, 2000·Molecular Aspects of Medicine·G Poli
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
Mar 28, 2003·Journal of Leukocyte Biology·Julia V DoviLuisa A DiPietro
Jul 24, 2003·The American Journal of Pathology·Grace Pinhal-EnfieldS Joseph Leibovich
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Robert F Diegelmann, Melissa C Evans
May 27, 2004·The American Journal of Pathology·M Carmen MontesinosBruce N Cronstein
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·James S SwaneyPaul A Insel
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janci L ChunnMichael R Blackburn
Nov 25, 2005·The New England Journal of Medicine·Maurits DemedtsUNKNOWN IFIGENIA Study Group
Jan 13, 2006·Kidney International·Youhua Liu
Jun 15, 2006·Archives of Internal Medicine·Arthur L KlatskyGary D Friedman
Jun 20, 2006·British Journal of Pharmacology·Edwin S L ChanBruce N Cronstein
Dec 16, 2006·Science·Yu ChenWolfgang G Junger
Feb 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhongsheng PengBruce N Cronstein
Apr 12, 2008·Purinergic Signalling·Karen M DwyerSimon C Robson
Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Pamela GasseIsabelle Couillin
Feb 18, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sigal NakavAmos Douvdevani
Aug 12, 2009·The International Journal of Biochemistry & Cell Biology·Luke J JanssenMartin R J Kolb
Sep 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniel J SchneiderMichael R Blackburn
Nov 18, 2009·Current Drug Targets·Antonino SpinelliMarco Montorsi
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Marek LommatzschMarco Idzko
Mar 4, 2010·Nature Reviews. Rheumatology·Edwin S L Chan, Bruce N Cronstein
Mar 20, 2010·Journal of Dermatological Science·Hiroshi OharaSetsuya Aiba
May 29, 2010·American Journal of Respiratory Cell and Molecular Biology·Monica LucattelliMarco Idzko
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Nicolas RiteauIsabelle Couillin
Sep 4, 2010·Journal of the American Society of Nephrology : JASN·Walter D ParkMark D Stegall
Feb 8, 2011·European Journal of Pharmacology·Tatsuro NakamuraHiroshi Ozaki
Apr 23, 2011·Journal of the American Society of Nephrology : JASN·Yingbo DaiYang Xia
May 12, 2011·Sub-cellular Biochemistry·Albert van der Vliet, Peter F Bove
Jun 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Filip KukulskiJean Sévigny
Jul 12, 2011·Expert Reviews in Molecular Medicine·Timothy J Koh, Luisa Ann DiPietro

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Citations

Sep 14, 2016·Trends in Molecular Medicine·Davide FerrariRoberto Gambari
Nov 11, 2016·Nature Reviews. Rheumatology·Bruce N Cronstein, Michail Sitkovsky
Jan 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaofei CongXiaoli Zhao
Jul 11, 2020·Journal of Cellular Physiology·Sheng WangXiongwen Lv
Jun 19, 2018·Frontiers in Physiology·Tinne C J MertensHarry Karmouty-Quintana
Apr 21, 2020·Journal of Clinical Immunology·Roberta PajnoAlessandro Aiuti
Oct 19, 2019·Cancers·Simone de LeveVerena Jendrossek
Apr 14, 2020·Cancer Cell International·Li-Li FengXin Wang
Dec 13, 2016·Journal of Cardiovascular Pharmacology·Abdullah KaplanFouad A Zouein
Apr 27, 2019·Frontiers in Immunology·Simone de LeveVerena Jendrossek
Aug 1, 2018·Frontiers in Immunology·Laura RennertFlorian Grahammer
Aug 1, 2019·American Journal of Physiology. Renal Physiology·Heather M PerryMark D Okusa
May 23, 2017·Frontiers in Pharmacology·Elizabeth A VecchioLauren T May
Aug 1, 2020·Frontiers in Immunology·Davide FerrariMarco Idzko
Oct 31, 2020·Frontiers in Immunology·Orazio FortunatoGiulia Bertolini
Feb 13, 2021·Purinergic Signalling·Julia Beatrice de AraújoDébora Tavares de Resende E Silva
Apr 9, 2021·Frontiers in Immunology·Paula Alvarenga BorgesClaudia Farias Benjamim
Nov 9, 2020·Biochemical Pharmacology·Herbert Zimmermann
May 7, 2020·Journal of Hepatology·Hui HanNatalia Nieto
Aug 13, 2021·BMC Musculoskeletal Disorders·Mengjie ChenDonghui Chen

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