Purinoceptor-evoked calcium signalling in human platelets

Prostaglandins, Leukotrienes, and Essential Fatty Acids
S O SageM P Mahaut-Smith

Abstract

ADP evokes a rise in platelet cytosolic Ca2+ concentration by stimulating Ca2+ entry and releasing Ca2+ from intracellular stores. Single cell studies indicate that the response consists of a series of spikes in cytosolic Ca2+. The release of stored Ca2+ is mediated by the generation of inositol 1,4,5-trisphosphate. Store depletion in turn leads to activation of a store-regulated Ca2+ entry pathway via a mechanism which appears to involve a protein tyrosine phosphorylation step. Preceding these events, ADP activates a receptor-operated non-selective cation channel, which mediates the entry of Ca2+ and Na+ with a latency of just a few milliseconds. Recent studies indicate that this channel is activated via a P2X1 purinoceptor at which ATP and diadenosine tetraphosphate are agonists. This receptor is distinct from that leading to the release of stored Ca2+ and to store-regulated Ca2+ entry.

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Citations

Oct 1, 1990·The Journal of Membrane Biology·M P Mahaut-Smith
Apr 13, 2011·Purinergic Signalling·Martyn P Mahaut-SmithRichard J Evans
Jun 28, 2000·Journal of the Autonomic Nervous System·N J Cusack, S M Hourani
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·R N Puri
Jan 30, 2002·British Journal of Pharmacology·Catherine VialRichard J Evans
Jul 9, 2008·The Journal of Biological Chemistry·Mirko MagnoneElena Zocchi
Jan 25, 2003·Tissue Engineering·Giuseppe IntiniRosemary Dziak
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Jun 19, 2004·Platelets·Martyn P Mahaut-SmithRichard J Evans
Feb 18, 2006·The Journal of Nutrition·Gillian L AllisonKhalid Rahman
Jun 2, 2020·Frontiers in Pharmacology·Leanne StokesElizabeth Allum

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