Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Mina RytenGeoffrey Burnstock

Abstract

ATP is an important extracellular signaling molecule mediating its effects by activation of P2X and P2Y receptors. P2 receptors are expressed during muscle development, and recent findings demonstrate that ATP can regulate myoblast proliferation and differentiation in vitro. However, the role of purinergic signaling during regeneration of injured skeletal muscle has not been investigated. To examine this process in a clinically relevant system, we used the mouse model of muscular dystrophy (mdx), in which muscle degeneration is rapidly followed by regeneration. The latter process, in vivo muscle regeneration, was the focus of this study, and to study the cellular mechanisms involved in it, a parallel study on normal rat skeletal myoblast cultures was conducted. Using immunohistochemistry, RT-PCR, and electrophysiology, we investigated the expression of the P2X1-7 receptor subtypes and the P2Y1,2,4,6 receptors. Experiments in vitro and in vivo demonstrated the sequential expression of the P2X5, P2Y1, and P2X2 receptors during the process of muscle regeneration. The P2X5 and P2Y1 receptors were expressed first on activated satellite cells, and the P2Y1 receptor was also expressed on infiltrating immune cells. Subsequent P2X2 rece...Continue Reading

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Citations

Oct 6, 2006·Pflügers Archiv : European journal of physiology·Gyula Péter SzigetiLászló Csernoch
Apr 12, 2008·Purinergic Signalling·Wiktor BanachewiczJolanta Barańska
May 2, 2012·Purinergic Signalling·Karina Kaczmarek-HájekAnnette Nicke
Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
May 23, 2006·Nature Reviews. Neuroscience·R Douglas Fields, Geoffrey Burnstock
Jan 13, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Geoffrey Burnstock
Feb 24, 2005·Neuromuscular Disorders : NMD·Taiwen JiangDariusz C Górecki
Apr 18, 2006·Bone·Isabel R OrrissTimothy R Arnett
Mar 3, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Isabelle MartellyBruno Constantin
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Davy YeungDariusz C Górecki
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
Jan 13, 2015·Molecular Medicine Reports·Li WeiYinghui Chen
Apr 15, 2011·American Journal of Physiology. Cell Physiology·Jesús García
Sep 18, 2015·Journal of Muscle Research and Cell Motility·Laszlo Csernoch, Vincent Jacquemond
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dorianna SandonàRomeo Betto
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Feb 11, 2011·Molecular and Cellular Biochemistry·Tiziana MartinelloRomeo Betto
Feb 13, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fei FeiHong-Hong Zhang
Aug 14, 2019·Frontiers in Cellular Neuroscience·Camille BlanchardKarine Massé
Dec 6, 2018·Brain and Neuroscience Advances·Geoffrey Burnstock
Jul 3, 2021·International Journal of Molecular Sciences·Marta TomczykRyszard T Smolenski

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