Purkinje cells of the cerebellar dorsal vermis: simple-spike activity during pursuit and passive whole-body rotation

Journal of Neurophysiology
Y ShinmeiKikuro Fukushima

Abstract

To track a slowly moving object during whole body rotation, smooth-pursuit and vestibularly induced eye movements must interact to maintain the accuracy of eye movements in space (i.e., gaze), and gaze movement signals must eventually be converted into eye movement signals in the orbit. To understand the role played by the cerebellar vermis in pursuit-vestibular interactions, in particular whether the output of the vermis codes gaze-velocity or eye-velocity, we examined simple-spike activity of 58 Purkinje (P-) cells in lobules VI-VII of head-stabilized Japanese monkeys that were trained to elicit smooth-pursuit eye movements and cancel their vestibuloocular reflex (VOR) during passive whole body rotation around horizontal, vertical, or oblique axes. All pursuit-sensitive vermal P-cells also responded during VOR cancellation, and the majority of them had peak modulation near peak stimulus velocity. The directions of maximum modulation during these two tasks were distributed in all directions with a downward preponderance. Using standard criteria, 40% of pursuit-sensitive vermal P-cells were classified as gaze-velocity. Other P-cells were classified either as eye/head-velocity group I (36%) that had similar preferred directions ...Continue Reading

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Citations

Oct 17, 2003·Journal of Neurophysiology·Megan R Carey, Stephen G Lisberger
Jul 25, 2009·Journal of Neurophysiology·Javier F Medina, Stephen G Lisberger
Sep 3, 2010·The Cerebellum·Jan VoogdChris I De Zeeuw
Aug 25, 2015·Frontiers in Systems Neuroscience·Ray X LeeChen-Tung Yen
Sep 29, 2011·Annals of the New York Academy of Sciences·Kikuro FukushimaTateo Warabi
Mar 23, 2007·Developmental Medicine and Child Neurology·Michael S SalmanMaureen Dennis
Aug 25, 2007·Cerebral Cortex·Takuya NittaKikuro Fukushima
Jun 3, 2008·Brain : a Journal of Neurology·Marianne Dieterich, Thomas Brandt
Sep 12, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Osamu Onodera
Feb 6, 2004·Journal of Neurophysiology·Richard J Krauzlis
Jan 30, 2004·Journal of Neurophysiology·Seiji OnoMichael J Mustari
Mar 1, 2012·Brain Structure & Function·Peter zu EulenburgM Dieterich
Nov 5, 2019·PloS One·Akiyoshi MatsugiYouichi Saitoh
Jan 26, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Americo A Migliaccio, Shaun R Watson
Dec 14, 2018·The Cerebellum·Sherry Y Tang, Aasef G Shaikh

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