PMID: 9435036Jan 1, 1997Paper

Purpura fulminans in pneumococcal sepsis: case report and review

Scandinavian Journal of Infectious Diseases
C T Carpenter, A B Kaiser

Abstract

Purpura fulminans is classically defined by ecchymotic skin lesions, fever, and hypotension. The majority of cases occur in association with bacterial sepsis, and disseminated intravascular coagulation (DIC) is usually present. Prompted by our experience with a patient with pneumococcal sepsis and purpura fulminans in whom hypotension was never observed, we evaluated the important parameters of sepsis in reports of this syndrome. 42 additional cases of pneumococcal bacteremia and purpura fulminans were identified. Hypotension was present in only 51%. Although DIC was present in 85% of patients, hypofibrinogenemia was documented in only 26%. By contrast, both hypotension and hypofibrinogenemia are present in the vast majority of patients described with purpura fulminans in association with meningococcal sepsis. These data confirm that hypotension is not a necessary feature of the syndrome of purpura fulminans associated with pneumococcal sepsis and suggest further that qualitative or quantitative differences exist in the DIC cascade of pneumococcal vs meningococcal sepsis.

References

May 1, 1976·Annals of Internal Medicine·J D Coonrod, R P Leach
Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M C Rodriguez BarradasC V Sanders
Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A BruynR van Furth
Jan 1, 1991·Critical Care Medicine·K JohansenD Ledbetter
Feb 1, 1991·Archives of Internal Medicine·T GiraudJ J Lanore
Oct 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G Har-ElM H Weiss
Jan 1, 1990·Intensive Care Medicine·E L MarcusM Sonnenblick
Jan 1, 1990·The Journal of Hand Surgery·R M Singer, J E Gorosh
May 1, 1990·Annals of Vascular Surgery·J R CohenB Douglas
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
Mar 1, 1986·Archives of Internal Medicine·M L HautekeeteM E Peetermans
Nov 1, 1986·Journal of the American Academy of Dermatology·P A RusonisS I Lamberg
Feb 1, 1974·American Journal of Diseases of Children·W H Toews, J W Bass
Aug 16, 1971·JAMA : the Journal of the American Medical Association·S C KarzG B Hart
Aug 1, 1967·Annals of Internal Medicine·W G McGeheeP F Hjort
Sep 7, 1970·JAMA : the Journal of the American Medical Association·M M AdnerJ D Sherman
Apr 1, 1981·The Journal of Clinical Investigation·E J BrownM M Frank
Jan 29, 1981·The New England Journal of Medicine·S W HoseaM M Frank
May 1, 1993·American Journal of Surgery·K Johansen, S T Hansen
May 11, 1995·The New England Journal of Medicine·E I TuomanenH R Masure
Sep 1, 1994·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·M OhnishiK Ooe
Jan 10, 1994·Archives of Internal Medicine·R C Bone
Aug 25, 1993·JAMA : the Journal of the American Medical Association·M LeviS J van Deventer
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D PowarsL Chan
Mar 1, 1993·The Pediatric Infectious Disease Journal·C A RyanS Tse
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R C MurphJ E Hernandez

❮ Previous
Next ❯

Citations

Sep 13, 2002·European Journal of Internal Medicine·H AkolJ van der Hoeven
Aug 10, 2002·Acta medica Austriaca·Ch Pechlaner
Apr 3, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yasuo OntachiShinji Nakao
Jan 16, 2002·The Pediatric Infectious Disease Journal·Chitsanu PancharoenUsa Thisyakorn
Aug 6, 2004·Pediatric Emergency Care·Antoni NogueraAntonio Palomeque
Nov 5, 2013·The American Journal of the Medical Sciences·Christine Saraceni, Daniel Schwed-Lustgarten
Dec 16, 2006·The American Journal of the Medical Sciences·Alex P BetrosianBanwari Agarwal
May 22, 2010·Hematology/oncology Clinics of North America·Thomas G DeLoughery
Aug 4, 2009·Emergency Medicine Clinics of North America·Thomas G DeLoughery
Aug 28, 2007·Journal of the American Academy of Dermatology·Mark D P DavisSteven Nelson
Aug 20, 2009·Annals of Tropical Paediatrics·I H IntanO Norlijah
Nov 23, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Petra Mariëlle MeinersPeter Dziewulski
Jul 5, 2005·Critical Care Clinics·Thomas G DeLoughery
Apr 14, 2015·Annals of Hematology·Maite Serrando i QuerolEsperanza Tuset Andujar
Aug 2, 2000·Critical Care Medicine·E RintalaP Kotilainen
Aug 23, 2018·Acta Anaesthesiologica Scandinavica·Pernille Ursin ReinOona Dunlop
Sep 3, 2005·American Journal of Hematology·Aytemiz GürgeyCigdem Altay
Dec 26, 2009·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Kenji KuboSatoru Matsushima
Apr 21, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·T J MarrieDean T Eurich
Jan 28, 2021·BMJ Case Reports·Laura Frances WalshBrian Wispelwey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.