PMID: 17391602Mar 30, 2007Paper

Purulent pericarditis in a patient with rheumatoid arthritis treated with etanercept and methotrexate

CJEM
David D SweetVinay Dhingra

Abstract

Purulent pericarditis is rarely seen in this post-antibiotic era. We report a case of spontaneous purulent pericarditis in a patient with rheumatoid arthritis being treated with etanercept, a tumour necrosis factor-alpha (TNF-alpha) antagonist, and methotrexate, an immunosuppressant. Both are disease-modifying anti-rheumatic drugs. We discuss the pathophysiology of purulent pericarditis and the recent literature on the infectious complications of TNF-alpha antagonists.

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