Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts

Current Transplantation Reports
Yuri L BoteonH Mergental

Abstract

Machine perfusion (MP) is a novel technology recently introduced in liver transplantation, redefining the current practice of organ preservation and pushing the limits of high-risk liver utilisation. This review highlights the key benefits of machine perfusion over conventional static cold storage (SCS), demonstrated in human liver research and clinical transplants. The first clinical trials have demonstrated both safety and feasibility of MP. The most recent transplant series and result from a randomised trial suggest the technology is superior to SCS. The key benefits include extended period of organ preservation, decreased incidence of early allograft dysfunction and reduction of biliary complications. Normothermic liver perfusion allows viability testing to guide transplantability of the highest-risk organs. This technology also provides opportunities for therapeutic interventions to improve liver function and quality in organs that are currently declined for clinical use. Machine perfusion is likely to transform the liver preservation pathway and to improve utilisation of high-risk grafts.

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Citations

Oct 30, 2018·World Journal of Transplantation·Yuri L BoteonSimon C Afford
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Dec 9, 2021·Artificial Organs·Yuri L BoteonPaulo N Martins

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Clinical Trials Mentioned

ISRCTN39731134
NCT01317342
NCT02584283
NCT02740608

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