Pushing the optical imaging limits of cancer with multi-frequency-band raster-scan optoacoustic mesoscopy (RSOM)

Neoplasia : an International Journal for Oncology Research
Murad OmarVasilis Ntziachristos

Abstract

Angiogenesis is a central cancer hallmark, necessary for supporting tumor growth and metastasis. In vivo imaging of angiogenesis is commonly applied, to understand dynamic processes in cancer development and treatment strategies. However, most radiological modalities today assess angiogenesis based on indirect mechanisms, such as the rate of contrast enhancement after contrast agent administration. We studied the performance of raster-scan optoacoustic mesoscopy (RSOM), to directly reveal the vascular network supporting melanoma growth in vivo, at 50 MHz and 100 MHz, through several millimeters of tumor depth. After comparing the performance at each frequency, we recorded, for the first time, high-resolution images of melanin tumor vasculature development in vivo, over a period of several days. Image validation was provided by means of cryo-slice sections of the same tumor after sacrificing the mice. We show how optoacoustic (photoacoustic) mesoscopy reveals a potentially powerful look into tumor angiogenesis, with properties and features that are markedly different than other radiological modalities. This will facilitate a better understanding of tumor's angiogenesis, and the evaluation of treatment strategies.

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Citations

Aug 28, 2016·Neoplasia : an International Journal for Oncology Research·Andrei ChekkouryVasilis Ntziachristos
Jul 8, 2016·Scientific Reports·Stephan KellnbergerVasilis Ntziachristos
Mar 23, 2017·Advanced Materials·Veronika MagdanzOliver G Schmidt
Apr 8, 2017·Chemical Communications : Chem Comm·Vipul GujratiVasilis Ntziachristos
May 26, 2017·IEEE Transactions on Medical Imaging·Elena MercepDaniel Razansky
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Nov 14, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B HindelangU Darsow
Jun 1, 2019·PloS One·Melanie A KimmMoritz Wildgruber
Oct 6, 2019·Scientific Reports·Bin RaoQuing Zhu
Sep 6, 2017·Scientific Reports·Mathias SchwarzVasilis Ntziachristos
Jul 26, 2018·Scientific Reports·Wei LiuJunjie Yao
Aug 1, 2018·Chemical Science·Sheryl RobertsThomas Reiner
Oct 21, 2018·Scientific Reports·Yuanhui HuangVasilis Ntziachristos
Mar 10, 2017·Chemical Society Reviews·X L Deán-BenD Razansky
Dec 2, 2017·Advanced Healthcare Materials·Alexander S TiminGleb B Sukhorukov
Dec 28, 2018·Light, Science & Applications·Stephan KellnbergerVasilis Ntziachristos
Apr 17, 2019·Nature Biomedical Engineering·Murad OmarVasilis Ntziachristos
Jul 25, 2019·Disease Models & Mechanisms·Emma BrownSarah E Bohndiek
Mar 14, 2020·Nature Biomedical Engineering·Katja HaedickeJan Grimm
Jan 13, 2017·Light, Science & Applications·Murad OmarVasilis Ntziachristos
Mar 7, 2019·Light, Science & Applications·Georg WissmeyerVasilis Ntziachristos
Aug 8, 2020·The British Journal of Dermatology·B HindelangV Ntziachristos
Dec 11, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·J WelzelG Pellacani
Nov 15, 2020·Photodiagnosis and Photodynamic Therapy·Terese von Knorring, Mette Mogensen
Jan 20, 2021·Scientific Reports·Zakiullah AliVasilis Ntziachristos
Aug 9, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giacomo PirovanoThomas Reiner
May 15, 2021·Experimental Dermatology·Xosé Luís Deán-Ben, Daniel Razansky

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Methods Mentioned

BETA
X-ray
optical microscopy
Fluorescence

Software Mentioned

RSOM50
RSOM

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