Putaminal abnormality on 3-T magnetic resonance imaging in early parkinsonism-predominant multiple system atrophy.

Journal of Neurology
Jee-Young LeeBeom S Jeon

Abstract

To evaluate the diagnostic value of putaminal abnormality on 3-T magnetic resonance imaging (MRI) for differentiating early parkinsonism-predominant multiple system atrophy (MSA-p) from Parkinson disease (PD) based on long-term clinical follow-up data. Totals of 23 clinical MSA-p (6 possible and 17 suspicious) and 50 PD patients were included. Subjects submitted to 3-T MRI at baseline and were followed up to substantiate the initial diagnosis. MRI findings were compared between MSA-p and PD patients based on the final diagnosis. Putaminal abnormalities were recorded as presence of atrophy, signal hypointensity, and abnormal disruption of the hyperintense lateral rim of the putamen. The sum scores for putaminal abnormality were calculated from the presence of each item. During the follow-up over 3 years, the diagnosis of MSA-p was supported in 17 patients (14 probable and 3 possible) and the diagnosis of PD was stable in all 50 patients. Putaminal abnormalities were more frequent in MSA-p (n = 17) than in PD (n = 50). A sum score of >1 on 3-T MRI had sensitivity, specificity, and positive- and negative-predictive values of 70.6, 93, 77.4, and 90.3%, respectively, for differentiating MSA-p from PD. Fourteen of the initial 23 clin...Continue Reading

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Citations

Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pettarusp M WadiaAnthony E Lang
Feb 11, 2015·Journal of Neurology·Han-Joon KimKurt A Jellinger
May 18, 2011·Current Opinion in Neurology·Gregor K WenningWerner Poewe
Jul 28, 2016·Movement Disorders Clinical Practice·Han-Joon KimVictor S C Fung
Aug 28, 2019·Journal of Parkinson's Disease·Morinobu SekiChristoph Scherfler
Oct 8, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kyum-Yil KwonKayeong Im

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