Putaminal dopamine depletion in de novo Parkinson's disease predicts future development of wearing-off

Parkinsonism & Related Disorders
Su Jin ChungYoung H Sohn

Abstract

The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson's disease. This retrospective cohort study included a total of 342 non-demented patients with de novo Parkinson's disease who underwent dopamine transporter positron emission tomography scans at their initial evaluation and received dopaminergic medications for 24 months or longer. Onset of wearing-off was determined based on patients' medical records at their outpatient clinic visits every 3-6 months. Predictive power of dopamine transporter activity in striatal subregions and other clinical factors for the development of wearing-off was evaluated by Cox proportional hazard models. During a median follow-up period of 50.2 ± 18.9 months, 69 patients (20.2%) developed wearing-off. Patients with wearing-off exhibited less dopamine transporter activity in the putamen, particularly the anterior and posterior putamens, compared to those without wearing-off. Multivariate Cox proportional hazard models revealed that dopamine transporter activities of the anterior (hazard ratio 0.556; p = 0.008) and whole putamens (hazard ratio 0.504; p = 0.025) were significant predictors of dev...Continue Reading

Citations

Jan 23, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Han-Joon KimCaroline H Williams-Gray
Mar 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni PalermoRoberto Ceravolo
Apr 4, 2020·Journal of Movement Disorders·Han Soo YooPhil Hyu Lee
Aug 14, 2019·Cells·Giovanni Palermo, Roberto Ceravolo
Mar 24, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Seok Jong ChungPhil Hyu Lee
Apr 26, 2021·Brain : a Journal of Neurology·Seong Ho JeongPhil Hyu Lee

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