Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population

International Journal of Cancer. Journal International Du Cancer
Guangfu JinHongbing Shen

Abstract

Matrix metalloproteinases (MMPs) play a crucial role in cancer progression and their over-expression is often associated with unfavorable survival of non-small cell lung cancer (NSCLC). Because genetic variants can alter expression level or biological activity of MMPs, we hypothesized that potentially functional single nucleotide polymorphisms (SNPs) in key MMP genes may be associated with the survival of NSCLC patients. We selected and genotyped 14 putative functional SNPs in six MMP genes (MMP1, MMP2, MMP3, MMP7, MMP9 and MMP12) using PCR-RFLP methods in 561 NSCLC patients. Kaplan-Meier method with the log-rank test and Cox proportional hazard models were used for the survival analyses. The C-1562T, Arg279Gln and Arg668Gln polymorphisms in MMP9 were significantly associated with survival of patients with NSCLC (log-rank p values = 0.032, 0.038 and 0.036, respectively). The C-1562T and Arg668Gln loci were in complete linkage disequilibrium (r(2) = 1). Patients carrying the 668Gln allele had improved survival with a median survival time (MST) of 51.6 months, compared with 21.8 months for those with the 668Arg/Arg genotype (log-rank p = 0.010). In contrast, the 279Gln/Gln genotype was associated with a significantly shortened MS...Continue Reading

References

Mar 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·G Murphy, V Knäuper
Sep 18, 1997·Journal of the National Cancer Institute·A F Chambers, L M Matrisian
Jun 5, 1999·Cancer Chemotherapy and Pharmacology·D E Kleiner, W G Stetler-Stevenson
Mar 5, 2002·Human Molecular Genetics·Ladina JoosAndrew J Sandford
May 2, 2002·Journal of the National Cancer Institute·Xifeng WuMargaret R Spitz
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Oct 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E LaackD K Hossfeld
Jan 14, 2003·Neuroscience Letters·Samir N KeladaHarvey Checkoway
Mar 18, 2004·Journal of the National Cancer Institute·Sholom WacholderNathaniel Rothman
Jun 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarada GurubhagavatulaDavid C Christiani
Oct 12, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kaoru OndoYoshihiko Maehara
Oct 16, 2004·Biochemical and Biophysical Research Communications·Enping XuXiaoping Xia
Nov 18, 2004·Journal of the National Cancer Institute·Hans-Hermann Dubben
Dec 21, 2004·Breast Cancer Research and Treatment·Fabienne GrieuBarry Iacopetta
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shun-Fa YangShu-Chen Chu
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Li SuDavid C Christiani
May 24, 2005·Biochimica Et Biophysica Acta·Mikael Björklund, Erkki Koivunen
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhibin HuHongbing Shen
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Nov 4, 2005·Breast Cancer Research and Treatment·Karolina PrzybylowskaJanusz Blasiak
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Jul 18, 2006·Nucleic Acids Research·Lucía CondeJoaquín Dopazo
Aug 31, 2006·British Journal of Cancer·F J G M KubbenH W Verspaget
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca Suk HeistDavid C Christiani
Jan 9, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jérôme RollinYves Gruel
Jun 16, 2007·Molecular Diagnosis & Therapy·Chun-Bao GuoXian-Qing Jin

❮ Previous
Next ❯

Citations

Sep 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Jing-Zhe SunMing Li
Apr 9, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ranjana SinghRama Devi Mittal
Mar 30, 2012·BMC Cancer·Patricia González-ArriagaAdonina Tardón
Oct 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wojciech J PiotrowskiJanusz Szemraj
Apr 28, 2011·Pharmacogenomics·Chandramu ChettySajani S Lakka
Jan 30, 2014·Cancers·Antonietta Rosella Farina, Andrew Reay Mackay
Apr 15, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wen GaoYongqian Shu
Jan 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne M HorganGeoffrey Liu
Apr 8, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Rieko OkadaUNKNOWN Japan Multi-institutional Collaborative Cohort Study Group
May 16, 2015·International Journal of Cancer. Journal International Du Cancer·Dorota ButkiewiczRafał Suwiński
May 27, 2016·International Journal of Cancer. Journal International Du Cancer·Kaipeng XieZhibin Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.