Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses.

BioMed Research International
Biao ChenJinping Chen

Abstract

Acne is the eighth most common disease worldwide. Disease burden of acne such as anxiety, reduced self-esteem, and facial scarring lowers the life quality of acne patients. Isotretinoin is the most potent treatment for moderate-severe acne. However, the adverse events of isotretinoin especially teratogenicity limit its use. This study aims at investigating the therapeutical mechanisms of isotretinoin using bioinformatics analysis. Differentially expressed genes (DEGs) were filtered from microarray datasets GSE10432, GSE10433, and GSE11792. Functional and pathway enrichment analyses of DEGs were performed. Protein-protein interaction (PPI) network and module analyses were also conducted based on DEGs. Using isotretinoin for 1 week, LCN2, PTGES, and GDF15 were upregulated and might mediate sebocytes apoptosis and thus decreased sebum production; CCL2 originated from activated TNF signaling pathway and S100A7 could be related with "acne-flare". While treating with isotretinoin for 8 weeks, key genes were downregulated, including HMGCS1, HMGCR, FDFT1, MVD, IDI1, and FDPS, which may be associated with decreased sebum synthesis; HMGCS1, HMGCR, and FDFT1 also probably associated with apoptosis of sebocytes. There were only two common ...Continue Reading

References

Mar 5, 2008·The Journal of Clinical Investigation·Amanda M NelsonDiane M Thiboutot
Nov 7, 2008·The Journal of Investigative Dermatology·Amanda M NelsonDiane M Thiboutot
May 5, 2009·Virchows Archiv : an International Journal of Pathology·Tsuguhiko SeoChoitsu Sakamoto
May 14, 2011·The British Journal of Dermatology·A M NelsonD M Thiboutot
Jan 31, 2012·Dermatologic Clinics·Lauren E BarnesSteven R Feldman
Feb 7, 2012·Journal of Dermatological Science·Jeong June ChoiMirim Jin
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastUNKNOWN European Dermatology Forum
Nov 26, 2013·Biochemical and Biophysical Research Communications·Aya OhkuniAkio Kihara
Jan 20, 2015·The British Journal of Dermatology·J K L Tan, K Bhate
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
Jan 1, 2015·Nature Reviews. Disease Primers·Sara Moradi TuchayiChristos C Zouboulis
May 26, 2017·The British Journal of Dermatology·I A VallerandS B Patten
Jun 10, 2017·Biotechnology Letters·Jia LiuTao Li
Jun 20, 2017·Expert Opinion on Investigational Drugs·Christos C ZouboulisHarald P M Gollnick
Sep 21, 2017·Journal of Translational Medicine·Bodo C Melnik
Nov 24, 2018·Personalized Medicine·Şükrü TüzmenSpyro Mousses
Jun 7, 2019·Cell Biochemistry and Function·Ghorban Ali TarfieiMohammad Hossein Ghahremani
Jul 10, 2019·BioMed Research International·Biao ChenYanhua Liang
Sep 10, 2019·The Journal of Dermatological Treatment·A PonaS L Taylor
Sep 27, 2019·Cancer Prevention Research·Tianshun ZhangZigang Dong
Dec 14, 2019·Physiological Reports·Zameer N DhananiOlasunkanmi A J Adegoke

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE11792
GSE10432
SEB-1
GSE10433

Methods Mentioned

BETA
biopsies

Software Mentioned

MCODE
GEO2R
Cytoscape
CytoHubba
STRING
DAVID

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Therapeutische Umschau. Revue thérapeutique
M Harms
Canadian Family Physician Médecin De Famille Canadien
Gurkirti BrarChristina Korownyk
La Revue du praticien
Laura Giraud-KerlerouxOlivier Chosidow
© 2021 Meta ULC. All rights reserved