Putative Gonadotropin-Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data

Journal of Alzheimer's Disease : JAD
Mark A SmithAlfred A Rimm

Abstract

Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management. Male Medicare beneficiaries aged 67 to 75 and hospitalized with prostate cancer (n = 115,789) were compared to three control groups: men of the same demographics undergoing a cholecystectomy (n = 97,267), herniorrhaphy (n = 68,778), or transurethral prostatectomy (n = 267,691). A proportion of the patients hospitalized with prostate cancer were assumed to have low concentrations of serum gonadotropins and sex steroids as a result of GnRH agonist therapy, while those in the control groups were assumed to have elevated gonadotropin but lowered sex steroid levels that are associated with andropause in this age group. The rates of development of select diagnoses of dementia, including AD, over a twelve-year...Continue Reading

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Citations

Aug 7, 2019·Journal of the Endocrine Society·Cecilie R BuskbjergRobert Zachariae
Jun 16, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Cornelie D AndelaA Edo Meinders

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Methods Mentioned

BETA
hormone replacement therapies
hormone replacement therapy
chemical castration
coronary artery bypass

Software Mentioned

MedPAR

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