Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
E E BenarrochP A Low

Abstract

We used double immunocytochemistry for α-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.

References

Jan 27, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Richard A ArmstrongNigel J Cairns
Oct 1, 2008·Annals of Neurology·Gregor K WenningMichael G Schlossmacher
Mar 14, 2012·Journal of Molecular Neuroscience : MN·Lisa SchwarzChristiane Richter-Landsberg

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Citations

Oct 16, 2015·Molecular Neurobiology·Giorgio BiasiottoIsabella Zanella
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Kurt A Jellinger
May 18, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Thilo van Eimeren

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