PMID: 9183437Apr 1, 1997Paper

Putative neurosurgical transmission of Creutzfeldt-Jakob disease with analysis of donor and recipient: agent strains

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
K H el HachimiJ F Foncin

Abstract

A woman, aged 59 years, underwent a cortical biopsy that led to the diagnosis of Creutzfeldt-Jakob disease (CJD). A man, aged 46 years, underwent cranial surgery in the same department 3 days later for brain contusion, with an uneventful recovery. Twenty six months later, he developed clinical signs of CJD with a typical EEG pattern. Both cases exhibited features of the 'ataxic' form of the disease with depletion of cerebellar granule cells, without kuru plaques or PrP deposits. PrP deposits were immuno-histochemically observed in the cerebrum, spinal cord and peripheral nerve. Molecular genetic analysis performed on brain tissue revealed the codon 129 polymorphism to be Met129Met in the donor and Met129Val in the recipient. The shared 'cerebellar' phenotype and the genotypic discrepancy between the two patients lead us to postulate that the 'cerebellar' agent strain plays a major role in CJD phenotype and transmission.

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Citations

Dec 11, 2007·American Journal of Infection Control·Jane D SiegelUNKNOWN Health Care Infection Control Practices Advisory Committee
Apr 9, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Paul Brown, Michael Farrell
Jun 24, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Stéphane Haïk, Jean-Philippe Brandel
Jun 3, 2016·Infectious Diseases of Poverty·Cao Chen, Xiao-Ping Dong
Jul 2, 2016·Neurosurgical Focus·David J BondaIgnazio Cali
Nov 2, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Fernando J García LópezJesús de Pedro-Cuesta
Jan 23, 2015·Journal of Virology·Atsushi KobayashiTetsuyuki Kitamoto
Oct 14, 2020·Biomedical Instrumentation & Technology·Camila Q M BrunaKazuko U Graziano
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Hasier ErañaJoaquín Castilla
Apr 4, 2021·International Journal of Molecular Sciences·Hideyuki HaraSuehiro Sakaguchi

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