PMID: 1353729Aug 7, 1992

Putative nucleotide binding sites of guinea pig liver transglutaminase

FEBS Letters
Y TakeuchiK N Lee


Three peptides corresponding to glycine-rich internal sequences of the guinea pig liver transglutaminase molecule were synthesized. These were peptide 1 (amino acid residues 520-544), peptide 2 (amino acid residues 345-367) and peptide 3 (amino acid residues 45-69). All of the synthetic peptides demonstrated significant binding ability for both ATP and GTP. Peptide 1 was the best protector of transglutaminase activity from both ATP and GTP inhibition, while peptides 2 and 3 protected the activity only from GTP inhibition. The data shown here lead us to propose putative binding site(s) for ATP and GTP guinea pig liver transglutaminase.


Jan 1, 1977·Advances in Protein Chemistry·J E Folk, J S Finlayson
Jul 15, 1991·Experientia·S Kawashima
Nov 1, 1990·Trends in Biochemical Sciences·M SarasteA Wittinghofer
Aug 15, 1989·Biochemical and Biophysical Research Communications·K N LeeM K Patterson
Nov 5, 1987·Biochimica Et Biophysica Acta·C M BergaminiL Poltronieri
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T E DeverW C Merrick
Dec 1, 1972·Analytical Biochemistry·L LorandL Cooperstein
Feb 26, 1968·Biochemical and Biophysical Research Communications·S Matacić, A G Loewy
Mar 1, 1968·Biochemistry·L LorandJ Bruner-Lorand
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J BirckbichlerH A Carter
Jan 1, 1984·Molecular and Cellular Biochemistry·L Lorand, S M Conrad


Apr 10, 1996·Biochimica Et Biophysica Acta·B M Fraij, R A Gonzales
Mar 23, 2004·Molecular and Cellular Neurosciences·Craig D C BaileyG V Johnson
Dec 12, 2001·Neurochemistry International·M LesortG V Johnson
Apr 5, 2000·Progress in Neurobiology·M LesortG V Johnson
Jan 4, 2012·Pharmacology & Therapeutics·Hilary Grosso, M Maral Mouradian
Dec 9, 2004·Journal of Neurochemistry·Craig D C Bailey, G V Johnson
Dec 15, 2010·Analytical Biochemistry·Johannes WolfThomas Mothes
Dec 6, 1996·The Journal of Biological Chemistry·T S LaiC S Greenberg
Dec 13, 2003·The Journal of Biological Chemistry·Tamara MilakovicG V Johnson
Mar 10, 1995·The Journal of Biological Chemistry·J M JeongL Lorand

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Guanosine Triphosphate
Cavia porcellus
Peptide Fragments

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.