PMID: 1353729Aug 7, 1992

Putative nucleotide binding sites of guinea pig liver transglutaminase

FEBS Letters
Y TakeuchiK N Lee

Abstract

Three peptides corresponding to glycine-rich internal sequences of the guinea pig liver transglutaminase molecule were synthesized. These were peptide 1 (amino acid residues 520-544), peptide 2 (amino acid residues 345-367) and peptide 3 (amino acid residues 45-69). All of the synthetic peptides demonstrated significant binding ability for both ATP and GTP. Peptide 1 was the best protector of transglutaminase activity from both ATP and GTP inhibition, while peptides 2 and 3 protected the activity only from GTP inhibition. The data shown here lead us to propose putative binding site(s) for ATP and GTP guinea pig liver transglutaminase.

References

Jan 1, 1977·Advances in Protein Chemistry·J E Folk, J S Finlayson
Jul 15, 1991·Experientia·S Kawashima
Nov 1, 1990·Trends in Biochemical Sciences·M SarasteA Wittinghofer
Aug 15, 1989·Biochemical and Biophysical Research Communications·K N LeeM K Patterson
Nov 5, 1987·Biochimica Et Biophysica Acta·C M BergaminiL Poltronieri
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T E DeverW C Merrick
Dec 1, 1972·Analytical Biochemistry·L LorandL Cooperstein
Feb 26, 1968·Biochemical and Biophysical Research Communications·S Matacić, A G Loewy
Mar 1, 1968·Biochemistry·L LorandJ Bruner-Lorand
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J BirckbichlerH A Carter
Jan 1, 1984·Molecular and Cellular Biochemistry·L Lorand, S M Conrad

Citations

Apr 10, 1996·Biochimica Et Biophysica Acta·B M Fraij, R A Gonzales
Mar 23, 2004·Molecular and Cellular Neurosciences·Craig D C BaileyG V Johnson
Dec 12, 2001·Neurochemistry International·M LesortG V Johnson
Apr 5, 2000·Progress in Neurobiology·M LesortG V Johnson
Jan 4, 2012·Pharmacology & Therapeutics·Hilary Grosso, M Maral Mouradian
Dec 9, 2004·Journal of Neurochemistry·Craig D C Bailey, G V Johnson
Dec 15, 2010·Analytical Biochemistry·Johannes WolfThomas Mothes
Dec 6, 1996·The Journal of Biological Chemistry·T S LaiC S Greenberg
Dec 13, 2003·The Journal of Biological Chemistry·Tamara MilakovicG V Johnson
Mar 10, 1995·The Journal of Biological Chemistry·J M JeongL Lorand

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Guanosine Triphosphate
Cavia porcellus
Liver
Peptide Fragments
Transglutaminases

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