Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer

Future Oncology
Katarzyna C MasoumiRamin Massoumi

Abstract

Deubiquitinating enzymes (DUBs) are specialized proteins that can recognize ubiquitinated proteins, and after direct interaction, deconjugate monomeric or polymeric ubiquitin chains, thus changing the fate of the substrates. This process is instrumental in mediating or changing downstream signaling pathways. Beside mutations and alterations in their expression levels, the activity and stability of deubiquitinating enzymes is vital for their function. SUMOylations consist of the conjugation of the small peptide SUMO to protein substrates which is very similar to ubiquitination in the mechanistic and machinery required. In this review, we will focus on how SUMOylation can regulate DUB enzymatic activity, stability or DUB interaction with partners and substrates, in cancer. Furthermore, we will discuss the impact of these recent findings in the identification of new potential tools for efficient anticancer treatment strategies.

References

Sep 12, 1998·Molecular Cell·J M DesterroR T Hay
Jun 3, 2000·Nature Genetics·G R BignellS Rasmussen
Mar 17, 2001·Nature Reviews. Neuroscience·J F Gusella, M E MacDonald
Dec 2, 2004·Biochimica Et Biophysica Acta·Alexander Y Amerik, Mark Hochstrasser
Dec 6, 2005·Cell·Sebastian M B NijmanRené Bernards
Mar 21, 2007·Nature Cell Biology·Stephanie CarterKaren H Vousden
Jun 15, 2007·Nature Cell Biology·Nikita PopovMartin Eilers
Sep 18, 2007·Cell Cycle·Nikita PopovMartin Eilers
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior
Jan 29, 2008·The Journal of Biological Chemistry·Jinmin GaoJun Zhou
Apr 29, 2008·Cellular and Molecular Life Sciences : CMLS·W Li, Y Ye
Jul 30, 2008·Cell·Florian BassermannMichele Pagano
Aug 9, 2008·The Biochemical Journal·Karen H Ventii, Keith D Wilkinson
Jan 24, 2009·Biochimica Et Biophysica Acta·Jung Hwa Kim, Sung Hee Baek
Jun 6, 2009·Annual Review of Biochemistry·Francisca E Reyes-TurcuKeith D Wilkinson
Nov 17, 2009·Experimental Cell Research·Michael CholayLaurent Daviet
Jan 16, 2010·Biochemical Society Transactions·Amanda Denuc, Gemma Marfany
Mar 30, 2010·Trends in Biochemical Sciences·Ramin Massoumi
May 14, 2010·The Biochemical Journal·Kevin A Wilkinson, Jeremy M Henley
Jul 2, 2010·The Journal of Pathology·Lei SunJun Zhou
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Jaclyn R Gareau, Christopher D Lima
Feb 25, 2011·Future Oncology·Ramin Massoumi
Apr 12, 2011·Cell Biochemistry and Biophysics·Benedikt M Kessler, Mariola J Edelmann
Jan 12, 2012·Journal of Skin Cancer·K C MasoumiRamin Massoumi

❮ Previous
Next ❯

Citations

Dec 12, 2017·Cancer Biomarkers : Section a of Disease Markers·Jie XiongZhitong Bing
Nov 30, 2018·Journal of Cellular Biochemistry·Li-Juan ZhaoHong-Min Liu
Mar 16, 2021·Frontiers in Oncology·Longtao YangHui Lin
Jun 29, 2021·Frontiers in Pharmacology·Yanfeng Wang, Feng Wang
Aug 22, 2021·Cellular Microbiology·Che Julius NgwaGabriele Pradel

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
polyubiquitination
two-hybrid
deubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Oncotarget
Rongbin WeiShangfeng Liu
Oncotarget
Urszula L McClurg, Craig N Robson
Molecular and Cellular Biology
Younghoon Kee, Tony T Huang
Protein Science : a Publication of the Protein Society
Cynthia Wolberger
© 2022 Meta ULC. All rights reserved