PMID: 3746382Jan 1, 1986Paper

Putrescine metabolism in human brain tumors

Journal of Neuro-oncology
S S GoldmanE S Flamm

Abstract

The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with 3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

References

Jan 1, 1976·Annual Review of Biochemistry·C W Tabor, H Tabor
Mar 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·O M RennertT D Miale
Oct 1, 1977·Journal of Biochemistry·K Sobue, T Nakajima
Nov 1, 1976·Experimental Neurology·H Sershen, A Lajtha
Dec 1, 1975·Journal of Cellular Physiology·O HebyH M Martinez
Dec 1, 1974·Archives of Biochemistry and Biophysics·A Lajtha, H Sershen
Jun 20, 1973·Biochimica Et Biophysica Acta·A Suzuki, M Goto
Dec 10, 1973·Biochemical and Biophysical Research Communications·U BachrachH Wiener
Aug 12, 1983·Science·N VolkowJ D Brodie
Nov 1, 1982·The American Journal of Physiology·A E Pegg, P P McCann
Jan 1, 1981·Neurochemistry International·N Seiler

❮ Previous
Next ❯

Citations

May 1, 1989·Journal of Neuro-oncology·P Elworthy, E Hitchcock
Oct 25, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Tarun SinghalJoseph Mantil
Jun 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R I ErnestusN Klug
Feb 1, 1993·Journal of Neurochemistry·R I ErnestusW Paschen
Jul 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abdel-Kareem AzabAbraham Rubinstein
Mar 24, 2006·Human Factors·Thurmon E LockhartJeffrey C Woldstad
Nov 1, 1989·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·P Ryan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.