Putting a stop to L,D-transpeptidases

Structure
Soumya De, Lawrence P McIntosh

Abstract

In this issue of Structure, Lecoq et al. investigated the structural and dynamic basis for the unexpected inhibition of peptidoglycan-crosslinking l,d-transpeptidases by carbapenem antibiotics. In addition to defining a neutral thiol-imidazole catalytic triad, their studies revealed extensive induced motions upon formation of a long-live covalent drug-enzyme complex.

References

Sep 8, 2005·The Journal of Biological Chemistry·Jean-Luc MainardiMichel Arthur
Jul 25, 2007·The Journal of Biological Chemistry·Jean-Luc MainardiMichel Arthur
Oct 21, 2009·Nature Chemical Biology·Andrew J Baldwin, Lewis E Kay
May 12, 2010·Current Opinion in Chemical Biology·Arthur F Kluge, Russell C Petter

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Citations

Mar 30, 2018·Annual Review of Biochemistry·Atanas D RadkovMichael S VanNieuwenhze

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