Putting together the clues of the everlasting neuro-cardiac liaison

Biochimica Et Biophysica Acta
Mauro FranzosoMarco Mongillo

Abstract

Starting from the late embryonic development, the sympathetic nervous system extensively innervates the heart and modulates its activity during the entire lifespan. The distribution of myocardial sympathetic processes is finely regulated by the secretion of limiting amounts of pro-survival neurotrophic factors by cardiac cells. Norepinephrine release by the neurons rapidly modulates myocardial electrophysiology, and increases the rate and force of cardiomyocyte contractions. Sympathetic processes establish direct interaction with cardiomyocytes, characterized by the presence of neurotransmitter vesicles and reduced cell-cell distance. Whether such contacts have a functional role in both neurotrophin- and catecholamine-dependent communication between the two cell types, is poorly understood. In this review we will address the effects of the sympathetic neuron activity on the myocardium and the hypothesis that the direct neuro-cardiac contact might have a key role both in norepinephrine and neurotrophin mediated signaling. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

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Citations

Dec 15, 2016·Scientific Reports·Hege E LarsenDavid J Paterson
Feb 28, 2017·The Journal of Physiology·Tania Zaglia, Marco Mongillo
Mar 11, 2018·The Journal of Physiology·Valentina PrandoMarco Mongillo
Jun 6, 2019·Methods and Protocols·Tania ZagliaMarco Mongillo
Nov 9, 2018·Frontiers in Cardiovascular Medicine·Maedeh ZamaniNgan F Huang
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Annika WinboJohanna M Montgomery
Dec 2, 2020·Journal of Cardiovascular Development and Disease·Laura Fedele, Thomas Brand
Jul 25, 2019·Progress in Biophysics and Molecular Biology·Anna Di BonaTania Zaglia
Dec 5, 2020·Journal of the American College of Cardiology·Luciano A SposatoUNKNOWN World Stroke Organisation Brain & Heart Task Force

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