PUVA-gel vs. PUVA-bath therapy for severe recalcitrant palmoplantar dermatoses. A randomized, single-blinded prospective study

Photodermatology, Photoimmunology & Photomedicine
Ralf SchienerM Kerscher

Abstract

In order to avoid unwanted effects of systemic psoralen and ultraviolet A (PUVA) therapy, various topical PUVA treatment modalities have been developed and are being increasingly used. However, up to now very few controlled studies comparing the therapeutic efficacy of different topical photochemotherapy modalities are available. Thus, the aim of our study was to compare the clinical efficacy of conventional PUVA-bath therapy to topical PUVA-gel therapy in patients with recalcitrant dermatoses of the palms and soles. Twenty patients with severe palmoplantar dermatoses or localized psoriatic plaques were enrolled in our observer-blinded, randomized half-sided study. The treatment modalities compared were: (i) aqueous 8-methoxypsoralen (8-MOP)-containing gel plus broadband UVA irradiation (PUVA-gel therapy) and (ii) 8-MOP bath of the hands and/or feet plus broadband UVA (PUVA-bath therapy). On the body half, which was randomized to PUVA-gel therapy, the median Area and Severity Index for palmoplantar dermatoses (ASIppd) decreased from 28 (range 6-56) to 1.5 (range 1-37, P = 0.00) after a median 33 (13-49) irradiations compared with a reduction from 26.5 (range 6-52.5) to 1.5 (range 0-38, P = 0.00) for PUVA-bath therapy. Both impr...Continue Reading

References

Sep 1, 1978·The British Journal of Dermatology·F GschnaitK Wolff
Jul 1, 1991·The British Journal of Dermatology·S E ThomasN Balac
May 1, 1991·Clinical and Experimental Dermatology·P Collins, S Rogers
Nov 1, 1990·Journal of the American Academy of Dermatology·M DavidM Borok
May 1, 1986·Journal of the American Academy of Dermatology·N J LoweL S Moy
Feb 1, 1994·The British Journal of Dermatology
May 1, 1993·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M C van PraagB J Vermeer
May 1, 1997·Journal of the American Academy of Dermatology·C M SchemppJ C Simon
Feb 1, 1997·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H StegeJ Krutmann
Jan 8, 1998·Archives of Dermatology·M LüftlM Röcken
Mar 5, 1998·Journal of the American Academy of Dermatology·W B ShelleyE D Shelley
Aug 7, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·S E ShephardR G Panizzon
Oct 21, 1998·Photodermatology, Photoimmunology & Photomedicine·G von KobyletzkiP Altmeyer
May 13, 1999·Photodermatology, Photoimmunology & Photomedicine·M Grundmann-KollmannM Kerscher
Jun 3, 1999·The British Journal of Dermatology·M Grundmann-KollmannM Kerscher
Jan 29, 2000·The British Journal of Dermatology·S M HalpernL E Rhodes

Citations

Aug 21, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H Stege
Jun 1, 2010·Dermatologic Clinics·William Abramovits, Patricia Granowski
May 28, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·E AdişenM A Gürer
Dec 21, 2007·Clinical and Experimental Dermatology·E AdişenM A Gürer
Jul 16, 2010·The Journal of Dermatology·Virendra N SehgalAlpna D Sharma
Sep 8, 2006·Actas dermo-sifiliográficas·C Ramírez, Sharon E Jacob
Jan 21, 2020·The Cochrane Database of Systematic Reviews·Grace ObeidLaurence Le Cleach
Nov 10, 2006·The Journal of Dermatological Treatment·Kassem RiadTrau Henri
Oct 31, 2015·Indian Journal of Dermatology, Venereology and Leprology·Sathish B Pai, Shricharith Shetty

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