PV+ Cells Enhance Temporal Population Codes but not Stimulus-Related Timing in Auditory Cortex

Cerebral Cortex
Bryan M. KrauseMatthew I. Banks

Abstract

Spatio-temporal cortical activity patterns relative to both peripheral input and local network activity carry information about stimulus identity and context. GABAergic interneurons are reported to regulate spiking at millisecond precision in response to sensory stimulation and during gamma oscillations; their role in regulating spike timing during induced network bursts is unclear. We investigated this issue in murine auditory thalamo-cortical (TC) brain slices, in which TC afferents induced network bursts similar to previous reports in vivo. Spike timing relative to TC afferent stimulation during bursts was poor in pyramidal cells and SOM+ interneurons. It was more precise in PV+ interneurons, consistent with their reported contribution to spiking precision in pyramidal cells. Optogenetic suppression of PV+ cells unexpectedly improved afferent-locked spike timing in pyramidal cells. In contrast, our evidence suggests that PV+ cells do regulate the spatio-temporal spike pattern of pyramidal cells during network bursts, whose organization is suited to ensemble coding of stimulus information. Simulations showed that suppressing PV+ cells reduces the capacity of pyramidal cell networks to produce discriminable spike patterns. By ...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Computational Neuroscience·Duho Sihn, Sung-Phil Kim
Nov 14, 2019·Cell Reports·Rasmus Kordt ChristensenTania Rinaldi Barkat

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