Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Robert SteigerwaltFrank Schönlau

Abstract

The growing numbers of diabetes cases in the developed world are followed by increasing numbers of people diagnosed with diabetic complications. Diabetic microangiopathies in the eye lead to the development of retinopathy involving gradual loss of vision. Previous studies with Pycnogenol showed effectiveness for stopping progression of preproliferative stages of retinopathy. The aim of our study was to show protective effects of Pycnogenol in early stages of retinopathy, characterized by mild to moderate retinal edema in the absence of hemorrhages or hard exudates in the macula center. Following treatment with Pycnogenol (24 patients) for 3 months, retinal edema score (dilated ophthalmology) and retinal thickness (high resolution ultrasound) showed statistically significant improvement as compared to the placebo group (22 patients), which showed negligible changes to baseline. Laser Doppler flow velocity measurements at the central retinal artery showed a statistically significant increase from 34 to 44 cm/s in the Pycnogenol group as compared to marginal effects in the control group. The major positive observation of this study is the visual improvement, which was subjectively perceived by 18 out of 24 patients in the Pycnogen...Continue Reading

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Citations

Jul 13, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Raimondo ForteGiovanni Cennamo
Jun 2, 2010·International Journal of Molecular Medicine·Irina G ObrosovaCarl-David Agardh
Jun 22, 2012·Journal of Postgraduate Medicine·B KumarS Srivastava
Apr 17, 2012·Drug Discovery Today·Gaurav K JainRoop K Khar
May 2, 2015·Phytotherapy Research : PTR·Om P Gulati
Nov 4, 2010·Journal of Ethnopharmacology·Alya MaimoonaKhalid Jameel
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Anel SchooneesJimmy Volmink
Feb 6, 2020·Journal of Clinical Medicine·Teresa Caro-OrdieresJesús Egido
Jul 15, 2020·Journal of Biochemical and Molecular Toxicology·Qiang ShiMingzhen Zhang
Sep 30, 2020·The Cochrane Database of Systematic Reviews·Nina U RobertsonJanicke Visser
Oct 23, 2019·Minerva cardioangiologica·Shu HuRoberta Luzzi
Oct 22, 2020·Nutrients·Ana L MatosPaulo F Santos
Nov 5, 2020·Expert Opinion on Drug Delivery·Deep Shikha SharmaSukriti Vishwas
Oct 13, 2020·International Journal of Antimicrobial Agents·Franziska Weichmann, Peter Rohdewald

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