PMID: 7026871May 1, 1981Paper

Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy

Kidney International
T E Miller, S Phillips

Abstract

We studied the relationship between infection, renal scarring, and antimicrobial therapy in pyelonephritis by an experimental model of the disease. Our specific concern was to identify those aspects of the acute phase of infection associated with the induction of the inflammatory response. Our hypothesis was that the degree of the inflammatory response and the extent of the subsequent lesion in the kidney depended on the rate at which a critical number of microorganisms was reached in the kidney. We proposed that the rapid increase in bacterial numbers in the kidney was the stimulus initiating the inflammatory response and not the total number of microorganisms in the kidney. In the experimental investigation, we treated animals with induced renal infection at varying intervals after the establishment of infection, and we determined the effect of antimicrobial therapy on the bacteriologic, gross, and histopathologic features of the disease. The early events relating to the bacterial invasion of the kidney were important determinants but the hypothesis needed extending to account for the fact that antimicrobial agents, administered after bacterial numbers had reached a plateau, still reduced markedly the damage to the kidney. Tw...Continue Reading

References

Feb 1, 1978·The Journal of Clinical Investigation·M P GlauserA I Braude
Jun 1, 1975·Kidney International·T E MillerS Burnham
Mar 1, 1973·The Journal of Infectious Diseases·T E Miller, K B Robinson

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Citations

Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H Olbing
Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U Jodal, J Winberg
Jan 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F GinevriR Gusmano
Jul 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B JakobssonU Berg
Aug 1, 1984·European Journal of Clinical Microbiology·T E Miller
Mar 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Burhan AksuMehmet Pul
Jul 13, 2002·The American Journal of Medicine·Linda M Dairiki Shortliffe, Jack D McCue
Mar 18, 2010·The Pediatric Infectious Disease Journal·Chi-Hui ChengTzou-Yien Lin
Dec 22, 2004·Kidney International·Majlis SvenssonCatharina Svanborg
Mar 1, 1983·Antimicrobial Agents and Chemotherapy·T Miller, S Phillips
May 1, 1986·Antimicrobial Agents and Chemotherapy·P R MeylanM P Glauser
Jul 1, 1994·Antimicrobial Agents and Chemotherapy·M TardifM G Bergeron
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·K KassirA Arrieta
Dec 1, 1983·Archives of Disease in Childhood·U B Berg, S B Johansson
Nov 1, 1988·Archives of Disease in Childhood·J M SmellieH M Bantock
Feb 1, 1994·Archives of Disease in Childhood·B JakobssonL Svensson
May 7, 1994·BMJ : British Medical Journal·J M SmellieN P Prescod
Oct 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R Beetz
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·B IványiJ Ormos
May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B S Arant
Jan 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A Roberts
Jul 1, 1996·Kidney International·M Linshaw
Jun 1, 1982·Kidney International·L B GuzeR J Glassock
Jun 20, 2002·Annals of Tropical Paediatrics·R D Wammanda, B O Ewa
Oct 1, 1984·European Journal of Cancer & Clinical Oncology·T Miller, N Bleumink
Jul 1, 1994·The Journal of Pediatrics·M S KramerE L Mills
Jul 1, 1993·Seminars in Nuclear Medicine·D F Eggli, M Tulchinsky
Jan 1, 1991·Scandinavian Journal of Urology and Nephrology·S H Jacobson
Sep 9, 2017·Disease Models & Mechanisms·Patrick D OlsonDavid A Hunstad
Apr 25, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Meral Torun BayramSalih Kavukçu
Jan 1, 1990·The Journal of Urology·J A RobertsG Baskin
Jan 1, 1986·Acta Medica Scandinavica. Supplementum·S H Jacobson

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