Abstract
Italian guideline suggests 10-day sequential or bismuth-based quadruple therapies for first-line Helicobacter pylori treatment. Comparison between these regimens is lacking. We assessed the efficacy of these therapies in clinical practice and evaluated the role of primary bacterial resistance toward clarithromycin and metronidazole. Consecutive patients with H. pylori infection were enrolled. Bacterial culture with antibiotics susceptibility testing was attempted in all cases. Patients received either a sequential therapy with esomeprazole 40 mg for 10 days plus amoxicillin 1000 mg for the first 5 days followed by clarithromycin 500 mg and tinidazole 500 mg (all twice daily) for the remaining 5 days, or bismuth-based therapy with esomeprazole 20 mg twice daily and Pylera 3 tablets four times daily for 10 days. H. pylori eradication was assessed by using C-urea breath test. A total of 495 patients were enrolled. Following sequential (250 patients) and quadruple (245 patients) therapies, the eradication rate were 92 and 91%, respectively, at intention-to-treat analysis and 96 and 97%, respectively, at per protocol analysis. Overall, the pattern of bacterial resistance did not significantly affect the cure rate, but the presence o...Continue Reading
References
Aug 1, 1996·Gastroenterology·J R Lambert
Jun 26, 2001·Helicobacter·R H PhillipsJ J Powell
Jun 15, 2007·Gut·Angelo ZulloDino Vaira
Jan 19, 2010·Internal and Emergency Medicine·Dino VairaJohn Holton
Aug 20, 2010·Internal and Emergency Medicine·Luigi GattaCarmelo Scarpignato
Nov 26, 2010·Internal and Emergency Medicine·Angelo ZulloCesare Hassan
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Dino VairaNimish Vakil
Feb 25, 2011·Lancet·Peter MalfertheinerUNKNOWN Pylera Study Group
Mar 8, 2012·Journal of Clinical Gastroenterology·Angelo ZulloCesare Hassan
Dec 27, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Giulia FioriniDino Vaira
Jun 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David Y GrahamMing-Shiang Wu
Aug 9, 2013·BMJ : British Medical Journal·Luigi GattaCarmelo Scarpignato
Aug 9, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Rocco Maurizio ZagariMichele Caselli
Dec 24, 2015·Alimentary Pharmacology & Therapeutics·I ThungM A Valasek
Feb 7, 2016·Clinics and Research in Hepatology and Gastroenterology·Nelly MullerJean-Charles Delchier
Jun 17, 2016·Journal of Gastrointestinal and Liver Diseases : JGLD·Vincenzo De FrancescoAngelo Zullo
Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel
Nov 9, 2016·BMC Medicine·Carmelo ScarpignatoUNKNOWN Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of Gene
Jul 12, 2017·The International Journal of Prosthodontics·Federico MandelliMarco Ferrari
Dec 8, 2017·The American Journal of Gastroenterology·Angelo ZulloDino Vaira
Citations
May 10, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Estelle GuiardPatrick Blin
May 24, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Manuel Castro FernándezMaría Rojas Feria
Jan 17, 2020·Antibiotics·Ilaria Maria SaracinoDino Vaira
Nov 30, 2018·Current Opinion in Gastroenterology·Sinéad M SmithDeirdre McNamara
Jan 10, 2020·Gut·Sho SuzukiKoichi Kawabe
Feb 27, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Valeria PalmitessaAntonio Lippolis
Feb 16, 2019·Helicobacter·Olga P NyssenJavier P Gisbert
Jul 29, 2020·Antibiotics·Su Young Kim, Jun-Won Chung
Jun 16, 2018·World Journal of Gastroenterology : WJG·Edith LahnerBruno Annibale
Sep 12, 2018·Helicobacter·Neil R O'MorainColm A O'Morain
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Jun 14, 2020·Helicobacter·Yunzhi ZouYong Xie
Oct 23, 2018·Helicobacter·Fernando Macías-GarcíaJuan Enrique Domínguez-Muñoz
Nov 3, 2020·Expert Opinion on Pharmacotherapy·Sotirios Georgopoulos, Vasilios Papastergiou
Mar 2, 2021·Frontiers in Cellular and Infection Microbiology·Margarita Camorlinga-PonceJavier Torres
Dec 19, 2020·Thérapie·Patrick BlinNicholas Moore
Jul 9, 2020·European Journal of Gastroenterology & Hepatology·Huimei XuDekui Zhang
May 18, 2021·Frontiers in Pharmacology·Antonietta G GravinaMarco Romano
Oct 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ioana Alexandra CardosSimona Cavalu
Nov 13, 2021·Helicobacter·Rocco Maurizio ZagariFranco Bazzoli
Dec 18, 2021·Medicine·Yaping CaoYongquan Shi