Pyloric gland adenoma in Lynch syndrome

The American Journal of Surgical Pathology
Seung Eun LeeKyoung M Kim

Abstract

The prevalence of gastric cancer associated with Lynch syndrome (LS) is highly variable, and the underlying histologic pathway or molecular mechanisms remain unclear. From 1995 to 2012, 15 patients had been treated for both gastric and colonic adenocarcinomas and diagnosed as LS. In all cases, pathologic review, immunohistochemical analysis for mismatch-repair proteins, and microsatellite instability (MSI) tests were performed. To confirm LS, germline mutation tests and multiplex ligation-dependent probe amplification were performed. All gastric and colonic carcinomas were MSI-high and lost expressions of MLH1/PMS2 in 11 (73%) cases and MSH2/MSH6 in 4 (27%) cases. Remarkably, in a patient with LS and germline mutation of MLH1 gene, pyloric gland adenoma (PGA) transformed to adenocarcinoma during follow-up. In 2 additional cases, PGA was found adjacent to advanced gastric cancers. All PGAs in LS patients were MSI-high and lost expression of mismatch-repair proteins (MLH1/PMS2 in 2 cases and MSH2/MSH6 in 1 case), whereas none of the 14 sporadic PGAs was MSI-high or had lost expression of mismatch-repair proteins. On the basis of these observations, although very rare, we suggest the possibility that PGA may be a precursor lesion ...Continue Reading

References

Jun 1, 1992·Gut·J R Jass, S M Stewart
Aug 14, 1998·Current Opinion in Oncology·H T Lynch, T Smyrk
Feb 24, 2001·Virchows Archiv : an International Journal of Pathology·G Oberhuber, M Stolte
Mar 7, 2003·The New England Journal of Medicine·Henry T Lynch, Albert de la Chapelle

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Citations

Aug 12, 2014·International Journal of Cancer. Journal International Du Cancer·So Young KangKyoung-Mee Kim
Mar 10, 2015·Seminars in Diagnostic Pathology·Changqing Ma, Reetesh K Pai
Apr 30, 2016·Archives of Pathology & Laboratory Medicine·Sangjeong Ahn, Do Youn Park
Aug 6, 2014·Journal of Clinical Pathology·Michael Vieth, Elizabeth Anne Montgomery
Feb 24, 2017·Der Pathologe·C Langner
Jan 2, 2016·International Journal of Surgical Pathology·Lodewijk A A BrosensElizabeth A Montgomery
Dec 27, 2017·Histopathology·Won-Tak ChoiGregory Y Lauwers
Oct 26, 2018·Archives of Pathology & Laboratory Medicine·Katrina Collins, Saverio Ligato
Aug 13, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Byung-Hoon MinKyoung-Mee Kim
Mar 14, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Xiaojuan Zheng
Jan 15, 2016·International Journal of Surgical Pathology·Dimitris I HatzibougiasJorge Albores-Saavedra
Jun 9, 2018·International Journal of Molecular Sciences·Mara FornasarigRenato Cannizzaro
Mar 15, 2016·The American Journal of Surgical Pathology·Rish K Pai, Reetesh K Pai
Jan 1, 2021·Histopathology·Bence KőváriGregory Y Lauwers
Jan 1, 2021·Histopathology·Irene GulloFátima Carneiro
Jan 21, 2021·Microorganisms·Simone BertzMichael Vieth
Aug 11, 2020·Surgical Pathology Clinics·Shoko VosLodewijk A A Brosens

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Methods Mentioned

BETA
light microscopy
PCR
dissection
biopsy

Software Mentioned

Genemapper

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